175281-76-2

Basic information

• Product Name: HYDROXYETHYL PHOTOLINKER
• Synonyms: HYDROXYETHYL PHOTOLINKER;4-[4-(1-HYDROXYETHYL)-2-METHOXY-5-NITROPHENOXY)BUTANOIC ACID;4-(4-(1-HYDROXYETHYL)-2-METHOXY-5-NITRO-PHENOXY)BUTYRIC ACID;4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butyric acid >=98.0% (HPLC);4-[4-(1-Hydroxyethyl)-2-methoxy-5-nitrophen;-2-methoxy-5-nitrophenoxy);4-(4-(1-Hydroxyethyl);4-(4-(1-Hydroxyethyl)-2-methoxy-5-nitrophenoxy)butyric acid≥ 98% (HPLC)
• CAS NO: 175281-76-2
• Molecular Formula: C₁₃H₁₇NO₇
• Molecular Weight: 299.28
• Product Categories: Aromatics
• Mol File: 175281-76-2.mol
• Article Data: 16

Chemical Properties

• Melting Point: 163-166 °C
• Boiling Point: 540.1°C at 760 mmHg
• Flash Point: 280.4°C
• Appearance: /
• Density: 1.333g/cm³
• Vapor Pressure: 1.7E-12mmHg at 25°C
• Refractive Index: 1.561
• Storage Temp.: 2-8°C
• Solubility: DMSO (Sparingly), Methanol (Slightly)
• PKA: 4.54±0.10(Predicted)
• BRN: 7717635
• CAS DataBase Reference: HYDROXYETHYL PHOTOLINKER(CAS DataBase Reference)
• NIST Chemistry Reference: HYDROXYETHYL PHOTOLINKER(175281-76-2)
• EPA Substance Registry System: HYDROXYETHYL PHOTOLINKER(175281-76-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 8-10
• Hazardous Substances Data: 175281-76-2(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

Different sources of media describe the Uses of 175281-76-2 differently. You can refer to the following data:
1. It is used as a photolabile linker for the preparation of carboxylic acids.
2. 4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid is used for preparation of photolabile linking groups for use in solid phase synthesis.

InChI:InChI=1/C13H17NO7/c1-8(15)9-6-11(20-2)12(7-10(9)14(18)19)21-5-3-4-13(16)17/h6-8,15H,3-5H2,1-2H3,(H,16,17)

Upstream product

• 2969-81-5 Ethyl 4-bromobutyrate 
• 498-02-2 1-(3-methoxy-4-hydroxyphenyl)ethanone 
• 188891-18-1 4-(4-acetyl-2-methoxy-5-nitrophenoxy)butanoic acid 
• 175281-79-5 methyl 4-(4-acetyl-2-methoxyphenoxy)butanoate 
• 174884-21-0 ethyl 4-(4-acetyl-2-methoxyphenoxy) butanoate 
• 198347-60-3 4-[4-(1-Hydroxy-ethyl)-2-methoxy-phenoxy]-butyric acid ethyl ester 
• 198347-61-4 4-[2-Methoxy-5-nitro-4-(1-nitrooxy-ethyl)-phenoxy]-butyric acid ethyl ester 
• 182122-16-3 methyl 4-[4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy]butyrate 
• 1073426-06-8 ethyl 4-(4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy) butanoate 
• 182297-45-6 methyl 4-(4-acetyl-2-methoxy-5-nitrophenoxy)butyrate 

Downstream Products

• 856241-09-3 pyrrolidine-1,2-dicarboxylic acid 1-(1-{5-methoxy-2-nitro-4-[3-(2-oxopropylcarbamoyl)propoxy]phenyl}ethyl) ester 
• 956347-50-5 C₃₈H₆₅N₅O₁₂ 
• 1091595-09-3 4-(4-(1-(acryloyloxy)ethyl)-2-methoxy-5-nitrophenoxy)butanoic acid 
• 1363555-53-6 C₁₆H₁₈ClNO₇ 
• 1356856-98-8 C₃₁H₅₂N₂O₆ 
• 1334290-05-9 4-(4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy)butan-1-ol 
• 1269794-14-0 2-((1-(4-(4-(2-(methacryloyloxy)ethylcarbamoyloxy)butoxy)-5-methoxy-2-nitro-phenyl)ethoxy)carbonylamino)ethyl methacrylate 
• 1352127-37-7 1,1'-(4,4'-(4,4'-(ethane-1,2-diylbis(azanediyl))bis(4-oxobutane-4,1-diyl))bis(oxy)bis(5-methoxy-2-nitro-4,1-phenylene))bis(ethane-1,1-diyl)bis(2-methyl acrylate) 
• 1352127-36-6 4-(4-(1-(methacryloyloxy)ethyl)-2-methoxy-5-nitrophenoxy)butanoic acid 
• 1351396-38-7 4-(4-(1-((4-azidobutananoyl)oxy)ethyl)-2-methoxy-5-nitrophenoxy)butanoic acid 
• 1375413-67-4 2,5-dioxopyrrolidin-1-yl 4-(4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy)butanoate 
• 1375413-68-5 1-(5-methoxy-2-nitro-4-(4-oxo-4-(prop-2-yn-1-ylamino)butoxy)phenyl)ethyl (4-nitrophenyl)carbonate 
• 1408057-90-8 C₁₉H₂₃N₃O₈ 
• 175281-77-3 4-(4-(1-bromoethyl)-2-methoxy-5-nitrophenoxy)butanoic acid 

Relevant articles and documents

Retro Diels-Alder Fragmentation of Fulvene-Maleimide Bioconjugates for Mass Spectrometric Detection of Biomolecules

Diels-Alder chemistry is a well-explored avenue for the synthesis of bioactive materials; however, its potential applications have recently expanded following the development of reactions that can be performed in buffered aqueous environments at low temperatures, including fulvene-maleimide [4 + 2] cycloadditions. In this study, we synthesized two novel amine-reactive fulvene linkers to demonstrate the application of this chemistry for generating mass spectrometry-cleavable labels (“mass tags”), which can be used for the labeling and detection of proteins. Successful conjugation of these linkers to maleimide-labeled peptides was observed at low temperatures in phosphate-buffered saline, allowing the non-destructive modification of proteins with such mass tags. The labile nature of fulvene-maleimide adducts in the gas phase also makes them suitable for both matrix-assisted laser desorption/ionization (MALDI) and electrospray ionization (ESI) mass spectrometric analysis. Unlike previous examples of MALDI mass tags, we show that fulvene-maleimide cycloaddition adducts fragment predictably upon gas-phase activation without the need for bulky photocleavable groups. Further exploration of this chemistry could therefore lead to new approaches for mass spectrometry-based bioassays.

PEG-PEI-modified gated N-doped mesoporous carbon nanospheres for pH/NIR light-triggered drug release and cancer phototherapy

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MOLECULAR LOGIC GATES FOR CONTROLLED MATERIAL DEGRADATION

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