175287-91-9

Upstream product

• 145628-18-8 ethyl 2-chloro-2-methylthio-acetate 
• 77198-99-3 N-(2-phenylethyl)benzenesulfonamide 
• 4455-13-4 methylthioacetic acid ethyl ester 

Downstream Products

• 50458-78-1 ethyl isoquinoline-1-carboxylate 
• 88612-00-4 3,4-dihydro-isoquinoline-1-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

IONIC liquid in organic synthesis: The Pictet-Spengler reaction

We have demonstrated the use of the room temperature ionic liquid, 1-butyl-3-methylimidazoliumhexafluorophosphate ([bmim]PF6), as an environmentally benign solvent for the preparation of 2-benzenesulfonyl-1,2,3,4-tetrahydroisoquinoline-1-carbox

A novel synthesis of isoquinolines containing an electron withdrawing substituent

3,4-Dihydroisoquinolines (10, 13) and isoquinolines (11), having various electron withdrawing substituent were synthesized in two steps from N- benzenesulfonyl- or N, N-dimethylsulfamoyl-β-phenethylamines (2 and 5). A novel cyclization method using ethyl chloro(methylthio)acetate (1) in the presence of SnCl4 as Lewis acid, followed by acid or base treatment provides the title compounds in good yield.

A novel cyclization of electron deficient N-benzenesulfonyl-β-phenethylamines using ethyl chloro(methylthio)acetate. Synthesis of ethyl 1,2,3,4-tetrahydroisoquinoline-1-carboxylates

The reaction of electron deficient N-benzenesufonyl-β-phenethylamines (2) with ethyl chloro(methylthio)acetate (1) gave ethyl 2-benzenesulfonyl-1,2,3,4-tetrahydroisoquinoline-1-carboxylates (3) in high yields. We examined the effects of a substituent on t