175288-41-2

Upstream product

• 109-56-8 i-propyl(2-(hydroxy)ethyl)amine 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 175288-51-4 (R)-2-{[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamoyloxy}-2-naphthalen-2-yl-propionic acid methyl ester 
• 175288-52-5 (S)-2-{[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamoyloxy}-2-naphthalen-2-yl-propionic acid methyl ester 
• 175288-47-8 (R)-2-{[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamoyloxy}-2-phenyl-propionic acid methyl ester 
• 175288-48-9 (S)-2-{[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamoyloxy}-2-phenyl-propionic acid methyl ester 
• 175288-53-6 [2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid (R)-1-methyl-1-naphthalen-2-yl-propyl ester 
• 175288-50-3 [2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid (R)-1-methyl-1-phenyl-butyl ester 
• 175288-49-0 [2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid (R)-1-methyl-1-phenyl-propyl ester 
• 175288-46-7 [2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid (S)-indan-1-yl ester 
• 175288-62-7 (R)-2-[(2-Hydroxy-ethyl)-isopropyl-carbamoyloxy]-2-phenyl-propionic acid methyl ester 
• 175288-63-8 (S)-2-[(2-Hydroxy-ethyl)-isopropyl-carbamoyloxy]-2-phenyl-propionic acid methyl ester 
• 175288-54-7 (S)-2-{[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamoyloxy}-2-naphthalen-2-yl-dithiopropionic acid methyl ester 
• 175288-55-8 (S)-1-{[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamoyloxy}-indan-1-carboxylic acid methyl ester 
• 175288-56-9 [2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid (R)-1-(1-hydroxy-1-methyl-ethyl)-indan-1-yl ester 
• 175288-44-5 [2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid (R)-1-naphthalen-2-yl-ethyl ester 

Relevant academic research and scientific papers

Synthesis of enantioenriched tertiary benzylic alcohols via stereospecific lithiation of secondary benzyl carbamates - Design of dialkylcarbamates, cleavable under basic, mild conditions

Enantiomerically enriched, secondary benzyl N-[2-(tert-butyldiphenylsilyloxy)ethyl]-N-isopropylcarbamates were prepared, lithiated, and stereospecifically substituted by several electrophiles. Deprotection under basic conditions furnished optically active tertiary benzylic alcohols and glycols or 2-hydroxy-2-arylalkanoic acid esters. In summary, the sequence achieves the stereospecific chain elongation of d1-synthons, derived from secondary benzyl alcohols.

Rapid syntheses of difluorinated polyols using a cleavable carbamate

Trifluoroethyl N-[2-(tert-butyldiphenylsilyloxy)ethyl]-N-isopropylcarbamate undergoes smooth dehydrofluorination-metallation followed by BF3·OEt2 mediated addition to aldehydes to afford a range of allylic alcohols; aldol reaction wi