175293-60-4

Upstream product

• 5392-10-9 2-bromo-4,5-dimethoxybenzaldehyde 
• 61203-53-0 2-iodo-4,5-dimethoxybenzaldehyde 
• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 634-36-6 1,2,3-trimethoxybenzene 
• 35323-09-2 (2-iodo-4,5-dimethoxyphenyl)acetic acid 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 103477-58-3 2-(2-bromo-4,5-dimethoxyphenyl)-1,3-dioxolane 
• 110451-87-1 2-bromomethyl-1-iodo-4,5-dimethoxybenzene 

Downstream Products

• 175293-61-5 3,4-Dimethoxy-7-(3,4,5-trimethoxy-phenyl)-bicyclo[4.2.0]octa-1,3,5-trien-7-ol 

Relevant academic research and scientific papers

Synthesis of Substituted Benzo[ b]thiophenes via Base-Promoted Domino Condensation-Intramolecular C-S Bond Formation

A novel synthesis of 2,3-substituted benzothiophenes is reported, involving a tandem base-mediated condensation of o-iodoarylacetonitriles/acetates/ketones with (hetero)aryldithioesters and an intramolecular C-S bond formation. The reaction affords divers

The asymmetric synthesis of aryltetralin lignans: (-)-isolariciresinol dimethyl ether and (-)-deoxysikkimotoxin

The total asymmetric syntheses of (-)-isolariciresinol dimethyl ether (6) and (-)-deoxysikkimotoxin (7) have been carried out, in an attempt to exploit a synthetic strategy recently developed for the synthesis of (-)-deoxypodophyllotoxin (1, R1 = -CH2-, Ar = 3,4,5-trimethoxyphenyl). In so doing, a generalized method for the synthesis of aryltetralin lignans has been developed that should be applicable to a variety of substitution patterns and stereochemistries. A one-pot, 100% regio-selective reduction-lactonization procedure has been developed for the conversion of the ester 18b to (-)-deoxysikkimotoxin, which gave 93% isolated yield in that step.