110451-87-1

Usage

General Description

Benzenemethanol, 2-iodo-4,5-dimethoxy- is a chemical compound that belongs to the class of aromatic compounds. It contains a benzene ring and a methanol group, as well as two methoxy groups and an iodine atom. Benzenemethanol, 2-iodo-4,5-dimethoxy- may be used in the synthesis of other organic compounds through various chemical reactions, and it may also have potential applications in the field of medicinal chemistry or as a precursor for the preparation of pharmaceuticals. However, it is important to handle this chemical with care and follow proper safety protocols, as it may have hazardous properties. Further research and testing may be necessary to fully understand the potential uses and risks associated with Benzenemethanol, 2-iodo-4,5-dimethoxy-.

Upstream product

• 93-03-8 (3,4-dimethoxyphenyl)methanol 
• 5392-10-9 2-bromo-4,5-dimethoxybenzaldehyde 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 61203-48-3 2-iodo-4,5-dimethoxybenzoic acid 
• 103477-58-3 2-(2-bromo-4,5-dimethoxyphenyl)-1,3-dioxolane 
• 58432-83-0 (4,5-dimethoxy-2-iodophenyl)methyl chloride 
• 61203-53-0 2-iodo-4,5-dimethoxybenzaldehyde 

Downstream Products

• 139557-86-1 Benzo[1,3]dioxole-5-carboxylic acid 2-iodo-4,5-dimethoxy-benzyl ester 
• 935521-27-0 4-[2-(tert-butyl-dimethyl-silanyloxymethyl)-4,5-dimethoxy-phenyl]-but-3-yn-2-one 
• 935521-39-4 4-[2-(tert-butyl-dimethyl-silanyloxymethyl)-4,5-dimethoxy-phenyl]-but-3-yn-2-ol 
• 146173-83-3 7-(3,4-Dimethoxyphenyl)-3,4-dimethoxybicyclo<4.2.0>octa-1,3,5-trien-7-ol 
• 63856-82-6 1-(3,4-Dimethoxy-phenyl)-2-(2-iodo-4,5-dimethoxy-phenyl)-ethanone 
• 175293-61-5 3,4-Dimethoxy-7-(3,4,5-trimethoxy-phenyl)-bicyclo[4.2.0]octa-1,3,5-trien-7-ol 
• 175293-60-4 2-(2-iodo-4,5-dimethoxyphenyl)-1-(3,4,5-trimethoxyphenyl)ethanone 
• 16877-49-9 (+/-)-trimethylpeltogynol 
• 141341-66-4 3-(2'-iodo-4',5'-dimethoxybenzyloxy)-7-methoxychromen-4-one 
• 1189788-40-6 C₉H₁₀IN₃O₂ 
• 293732-31-7 1-(2-iodo-4,5-dimethoxybenzyl)pyrrole-2-carboxylic acid diethyl amide 
• 851384-83-3 [1-(2-iodo-4,5-dimethoxy-benzyl)-1H-pyrrol-2-yl]-morpholin-4-yl-methanone 
• 916977-23-6 methyl 7-(4,5-dimethoxy-2-vinylbenzyl)-1-trimethylsiloxybicyclo[4.1.0]heptane-7-carboxylate 
• 916977-18-9 methyl 7-(2-iodo-4,5-dimethoxybenzyl)-1-trimethylsiloxybicyclo[4.1.0]heptane-7-carboxylate 

Relevant academic research and scientific papers

Total Synthesis of (±)-Pestalachloride C and (±)-Pestalachloride D through a Biomimetic Knoevenagel/Hetero-Diels-Alder Cascade

A concise total synthesis of (±)-pestalachloride C and (±)-pestalachloride D was achieved through a Knoevenagel/hetero-Diels-Alder cascade reaction to test the nonenzymatic biosynthetic hypothesis of Shao, Wang, and co-workers. The cascade reaction generates a mixture of racemic indano[2,1-c]chromans like those found in the natural products.

Palladium-catalyzed insertion of N-tosylhydrazones for the synthesis of isoindolines

Isoindolines are synthesized by palladium-catalyzed coupling reaction of N-(2-iodobenzyl) anilines with α,β-unsaturated N-tosylhydrazones. The reaction has several potential advantages: (1) toleration of a wide range of functional groups, (2) easy to handle and with mild conditions, (3) enriches the isoindoline family, (4) two new bonds form in one step.

Phosphine/palladium-catalyzed syntheses of alkylidene phthalans, 3-deoxyisoochracinic acid, isoochracinic acid, and isoochracinol

In this study we used sequential catalysis-PPh3-catalyzed nucleophilic addition followed by Pd(0)-catalyzed Heck cyclization-to construct complex functionalized alkylidene phthalans rapidly, in high yields, and with good stereoselectivities (E/Z ratios of up to 1:22). The scope of this Michael-Heck reaction includes substrates bearing various substituents around the alkylidene phthalan backbone. Applying this efficient sequential catalysis, we accomplished concise total syntheses of 3-deoxyisoochacinic acid, isoochracinic acid, and isoochracinol.

An efficient entry to pyrrolo[1,2-b]isoquinolines and related systems through Parham cyclisation

Aryllithiums generated by lithium-iodine exchange undergo intramolecular cyclisation to give pyrrolo[1,2-b]isoquinolines, in high yields. The best results were obtained when Weinreb or morpholine amides were used as internal electrophiles. The procedure h

Simple and regioselective oxyiodination of aromatic compounds with ammonium iodide and Oxone

Oxyiodination of aromatic compounds using NH4I and Oxone gives high yields and selectivity. A simple method for the iodination of aromatic compounds using NH4I as the iodine source and Oxone as the oxidant is described.

Parham-type cycliacylation with Weinreb amides. Application to the synthesis of fused indolizinone systems

(Matrix presented) Weinreb amides behave as efficient internal electrophiles in Parham-type cycliacylation reactions. Thus, aryl- and heteroaryllithiums generated by lithium-halogen exchange undergo intramolecular cyclization to give fused indolizinone systems as pyrrolo[1,2-b]isoquinolines, thieno[2,3-f]indolizinones, and pyrrolo[1,2-b]acridinones in high yields.

Carbopalladation of nitriles: Synthesis of benzocyclic ketones and cyclopentenones via Pd-catalyzed cyclization of ω-(2-iodoaryl)alkanenitriles and related compounds

An efficient procedure for the synthesis of 2,2-disubstituted benzocyclic ketones by intramolecular carbopalladation of nitriles has been developed. The cyclization of substituted 3-(2-iodoaryl)-propanenitriles affords indanones in high yields. The reaction is compatible with a wide variety of functional groups. This methodology has been extended to the synthesis of tetralones and cyclopentenones.

A Convenient Strategy for the Synthesis of 4,5-Bis(o-haloaryl)isoxazoles

A series of new 1,2-bis(o-haloaryl)ethanones is efficiently prepared and applied to the synthesis of 4,5-bis(o-haloaryl)isoxazoles. Isolation of intermediate hydroxyisoxazolines, which are structurally examined, provides a definitive proof for a heterocyclization mechanism based on an amine exchange process. The isolation and X-ray crystallographic studies of significant side products such as benzamides and triarylpropionitriles are also described.

The asymmetric synthesis of aryltetralin lignans: (-)-isolariciresinol dimethyl ether and (-)-deoxysikkimotoxin

The total asymmetric syntheses of (-)-isolariciresinol dimethyl ether (6) and (-)-deoxysikkimotoxin (7) have been carried out, in an attempt to exploit a synthetic strategy recently developed for the synthesis of (-)-deoxypodophyllotoxin (1, R1 = -CH2-, Ar = 3,4,5-trimethoxyphenyl). In so doing, a generalized method for the synthesis of aryltetralin lignans has been developed that should be applicable to a variety of substitution patterns and stereochemistries. A one-pot, 100% regio-selective reduction-lactonization procedure has been developed for the conversion of the ester 18b to (-)-deoxysikkimotoxin, which gave 93% isolated yield in that step.

Synthesis of ring-halogenated 3,4-dimethoxyphenylethanolamine derivatives: New β-adrenoceptor antagonists

A series of ring-halogenated derivatives (bromo and iodo) of [2-(3,4-dimethoxyphenyl)-2-hydroxyethyl]isopropylamine and [2-(3,4-dimethoxyphenyl)-2-methoxyethyl]isopropylamine was synthesized from benzaldehyde derivatives, via (halo-3,4-dimethoxyphenyl)ethylene oxide compounds. The compounds were tested as β-adrenoceptor antagonists on isolated guinea-pig tracheal (β2-adrenoceptors) and guinea-pig atrial (β1-adrenoceptors) muscle strips. Compounds halogenated in the 2-and 5-positions of the aromatic ring are potent β2-adrenoceptor antagonists, whereas halogenation of the 6-position of the aromatic ring leads to compounds which are weak β-adrenoceptor antagonists. β1-Selective drugs of very low potency were obtained when the β-hydroxyl group was replaced by a methoxy group.