1753-48-6

Basic information

• Product Name: 2-Aminopyrimidine-5-carbonitrile
• Synonyms: 2-AMINOPYRIMIDINE-5-CARBONITRILE;5-Pyrimidinecarbonitrile, 2-amino- (7CI,8CI,9CI);2-AMINOPYRIMIDINE-5-CARBONITRILE, 95+%;2-Amino-5-pyrimidinecarbonitrile;Zinc02559851;2-AMino-5-cyanopyriMidin;5-Cyano-2-pyriMidinaMine;2-Amino-5-cyanopyrimidine, 2-Amino-5-cyano-1,3-diazine
• CAS NO: 1753-48-6
• Molecular Formula: C₅H₄N₄
• Molecular Weight: 120.11
• Product Categories: PYRIMIDINE;API intermediates;Heterocycle-Pyrimidine series
• Mol File: 1753-48-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 300-310 °C (decomp)
• Boiling Point: 387.862 °C at 760 mmHg
• Flash Point: 188.372 °C
• Appearance: /
• Density: 1.346 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.6
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 0.61±0.10(Predicted)
• CAS DataBase Reference: 2-Aminopyrimidine-5-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Aminopyrimidine-5-carbonitrile(1753-48-6)
• EPA Substance Registry System: 2-Aminopyrimidine-5-carbonitrile(1753-48-6)

Safety Data

• Statements: 41
• Safety Statements: 26-39
• Hazardous Substances Data: 1753-48-6(Hazardous Substances Data)

Usage

Uses

2-Aminopyrimidine-5-carbonitrile is used for the preparation of pyrazinone and pyridinone derivatives as thrombin inhibitors.

InChI:InChI=1/C5H4N4/c6-1-4-2-8-5(7)9-3-4/h2-3H,(H2,7,8,9)

Upstream product

• 557-21-1 zinc(II) cyanide 
• 7752-82-1 5-bromo-2-aminopyrimidine 
• 544-92-3 copper(I) cyanide 
• 91-22-5 quinoline 
• 149139-41-3 α-cyano-β-dimethylaminoacrolein 
• 594-14-9 guanidinium sulfate 

Downstream Products

• 1753-50-0 2-chloropyrimidine-5-carbonitrile 
• 5388-17-0 2-Amino-5-carbamoyl-pyrimidin 
• 1057677-49-2 2-[4-(4-benzyl-phthalazin-1-yl)-piperazin-1-yl]-pyrimidine-5-carbonitrile 
• 672324-80-0 5-(aminomethyl)pyrimidin-2-amine 
• 369384-15-6 2-tert-butoxycarbonylimino-5-{[2-(6-methyl-2-oxo-3-phenylmethanesulfonylamino-2H-pyridin-1-yl)-acetylamino]-methyl}-2H-pyrimidine-1-carboxylic acid tert-butyl ester 
• 454483-45-5 5-aminomethyl-1,4,5,6-tetrahydro-pyrimidin-2-ylamine 

Relevant articles and documents

ORGANIC FLUORESCENT LUMINESCENT MATERIAL AND ORGANIC ELECTROLUMINESCENT DEVICE

An organic fluorescent luminescent material and an organic electro-luminescence device are provided. The organic fluorescent luminescent material may be represented by the formula, (Ar)-(Ph)-(X), wherein Ar is Ph include at least one benzene ring, X is a six-membered aromatic ring, and at least one nitrogen atom is located on the six-membered aromatic ring. The organic fluorescent luminescent material can be used in organic electro-luminescence devices.

SYNTHESIS WITH NITRILES: 92. SYNTHESIS OF 5-FORMYLCYTOSINE DERIVATIVES

The reactivity of 3-dimethylamino-2-formylpropenenitrile (1) with various amino compounds is studied.Thus, condensation of 1 with anilines gives the corresponding azomethines (2a-c).Reaction of 1 with thiourea and guanidine resp., leads to 5-formylthiocyt