1753-48-6

Usage

Uses

Used in Pharmaceutical Industry:
2-Aminopyrimidine-5-carbonitrile is used as a key intermediate for the synthesis of pyrazinone and pyridinone derivatives, which are known as thrombin inhibitors. Thrombin inhibitors play a crucial role in the treatment of various medical conditions, such as coagulation disorders, thrombosis, and stroke, by preventing the clotting of blood and reducing the risk of blood clot formation.
The compound's utility in the pharmaceutical industry lies in its ability to be further modified and functionalized to develop novel thrombin inhibitors with improved potency, selectivity, and pharmacokinetic properties. This makes 2-Aminopyrimidine-5-carbonitrile a valuable building block for the design and development of innovative therapeutic agents targeting thrombin-mediated diseases.

InChI:InChI=1/C5H4N4/c6-1-4-2-8-5(7)9-3-4/h2-3H,(H2,7,8,9)

Upstream product

• 7752-82-1 5-bromo-2-aminopyrimidine 
• 544-92-3 copper(I) cyanide 
• 557-21-1 zinc(II) cyanide 
• 91-22-5 quinoline 
• 149139-41-3 α-cyano-β-dimethylaminoacrolein 
• 594-14-9 guanidinium sulfate 

Downstream Products

• 454483-45-5 5-aminomethyl-1,4,5,6-tetrahydro-pyrimidin-2-ylamine 
• 369384-15-6 2-tert-butoxycarbonylimino-5-{[2-(6-methyl-2-oxo-3-phenylmethanesulfonylamino-2H-pyridin-1-yl)-acetylamino]-methyl}-2H-pyrimidine-1-carboxylic acid tert-butyl ester 
• 1753-50-0 2-chloropyrimidine-5-carbonitrile 
• 672324-80-0 5-(aminomethyl)pyrimidin-2-amine 
• 1057677-49-2 2-[4-(4-benzyl-phthalazin-1-yl)-piperazin-1-yl]-pyrimidine-5-carbonitrile 
• 5388-17-0 2-Amino-5-carbamoyl-pyrimidin 

Relevant academic research and scientific papers

ORGANIC FLUORESCENT LUMINESCENT MATERIAL AND ORGANIC ELECTROLUMINESCENT DEVICE

An organic fluorescent luminescent material and an organic electro-luminescence device are provided. The organic fluorescent luminescent material may be represented by the formula, (Ar)-(Ph)-(X), wherein Ar is Ph include at least one benzene ring, X is a six-membered aromatic ring, and at least one nitrogen atom is located on the six-membered aromatic ring. The organic fluorescent luminescent material can be used in organic electro-luminescence devices.

Non-covalent thrombin inhibitors featuring P3-heterocycles with P1-monocyclic arginine surrogates

Investigations on P2-P3-heterocyclic dipeptide surrogates directed towards identification of an orally bioavailable thrombin inhibitor led us to pursue novel classes of achiral, non-covalent P1-arginine derivatives. The design, synthesis, and biological activity of inhibitors NC1-NC30 that feature three classes of monocyclic P1-arginine surrogates will be disclosed: (1) (hetero)aromatic amidines, amines and hydroxyamidines, (2) 2-aminopyrazines, and (3) 2-aminopyrimidines and 2-aminotetrahydropyrimidines.

SYNTHESIS WITH NITRILES: 92. SYNTHESIS OF 5-FORMYLCYTOSINE DERIVATIVES

The reactivity of 3-dimethylamino-2-formylpropenenitrile (1) with various amino compounds is studied.Thus, condensation of 1 with anilines gives the corresponding azomethines (2a-c).Reaction of 1 with thiourea and guanidine resp., leads to 5-formylthiocyt