17532-22-8Relevant academic research and scientific papers
Identification of neuropeptide s antagonists: Structure-Activity relationship studies, x-ray crystallography, and in vivo evaluation
Hassler, Carla,Zhang, Yanan,Gilmour, Brian,Graf, Tyler,Fennell, Timothy,Snyder, Rodney,Deschamps, Jeffrey R.,Reinscheid, Rainer K.,Garau, Celia,Runyon, Scott P.
, p. 731 - 744 (2014)
Modulation of the neuropeptide S (NPS) system has been linked to a variety of CNS disorders such as panic disorder, anxiety, sleeping disorders, asthma, obesity, PTSD, and substance abuse. In this study, a series of diphenyltetrahydro-1H-oxazolo[3,4-α]pyr
Identifying structural features on 1,1-diphenyl-hexahydro-oxazolo[3,4-a]pyrazin-3-ones critical for Neuropeptide S antagonist activity
Zhang, Yanan,Gilmour, Brian P.,Navarro, Hernan A.,Runyon, Scott P.
scheme or table, p. 4064 - 4067 (2009/04/06)
A series of 7-substituted 1,1-diphenyl-hexahydro-oxazolo[3,4-a]pyrazin-3-ones were synthesized and tested for Neuropeptide S (NPS) antagonist activity. A concise synthetic route was developed, which features a DMAP catalyzed carbamate formation. 4-Fluorob
