17538-93-1Relevant academic research and scientific papers
Enantioselective oxidative gold catalysis enabled by a designed chiral P,N-bidentate ligand
Ji, Kegong,Zheng, Zhitong,Wang, Zhixun,Zhang, Liming
supporting information, p. 1245 - 1249 (2015/01/30)
A newly developed P,N-bidentate ligand enables enantioselective intramolecular cyclopropanation by a reactive α-oxo gold carbene intermediate generated in situ. The ligand design is based on our previously proposed structure (with a well-organized triscoordinated gold center) of the carbene intermediate in the presence of a P,N-bidentate ligand. A C2-symmetric piperidine ring was incorporated in the ligand as the nitrogen-containing moiety. A range of racemic transformations of α-oxo gold carbene intermediates have been developed recently, and this new class of chiral ligands could enable their modification for asymmetric synthesis, as demonstrated in this study.
