81462-47-7

Upstream product

• 83179-38-8 2-(α-chlorovinyl)stilbene 
• 81462-40-0 2-(β-chlorovinyl)stilbene 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 1080-32-6 O,O-diethyl benzylphosphonate 
• 6630-33-7 ortho-bromobenzaldehyde 
• 26260-02-6 2-iodobenzaldehyde 
• 5025-41-2 1-iodo-2-[(E)-2-phenylethenyl]benzene 
• 1066-54-2 trimethylsilylacetylene 
• 77123-58-1 2-[2-(trimethylsilyl)ethynyl]benzaldehyde 
• 36901-75-4 (2-bromobenzyl)triphenylphosphonium bromide 
• 54737-45-0 (E)-2-bromostilbene 
• 63104-89-2 1-formyl-2-(2-phenylethenyl)-benzene 
• 81462-40-0 2-(2-chlorovinyl)stilbene 

Downstream Products

• 612-94-2 2-phenylnaphthalene 
• 83179-47-9 phenanthrenylacetylene 
• 1604820-81-6 (E)-N-benzyl-N-(2-bromo-4,5-dimethoxybenzyl)-3-(2-styrylphenyl)-1-p-tolylprop-2-yn-1-amine 
• 1604820-58-7 (E)-2-benzyl-6,7-dimethoxy-4-(2-phenyl-1H-inden-1-ylidene)-3-p-tolyl-1,2,3,4-tetrahydroisoquinoline 
• 1604820-83-8 (E)-N-benzyl-N-(2-bromo-4,5-dimethoxybenzyl)-1-(3-nitrophenyl)-3-(2-styrylphenyl)prop-2-yn-1-amine 
• 1604820-60-1 (E)-2-benzyl-6,7-dimethoxy-3-(3-nitrophenyl)-4-(2-phenyl-1H-inden-1-ylidene)-1,2,3,4-tetrahydroisoquinoline 
• 1604820-86-1 (E)-N-benzyl-N-(2-bromo-4,5-dimethoxybenzyl)-1-(furan-3-yl)-3-(2-styrylphenyl)prop-2-yn-1-amine 
• 1604820-63-4 (E)-2-benzyl-3-(furan-3-yl)-6,7-dimethoxy-4-(2-phenyl-1H-inden-1-ylidene)-1,2,3,4-tetrahydroisoquinoline 
• 1604820-85-0 (E)-N-benzyl-N-(2-bromo-4,5-dimethoxybenzyl)-3-(2-styrylphenyl)-1-(thiophen-2-yl)prop-2-yn-1-amine 
• 1604820-62-3 (E)-2-benzyl-6,7-dimethoxy-4-(2-phenyl-1H-inden-1-ylidene)-3-(thiophen-2-yl)-1,2,3,4-tetrahydroisoquinoline 
• 1604820-61-2 (E)-2-benzyl-6,7-dimethoxy-4-(2-phenyl-1H-inden-1-ylidene)-1,2,3,4-tetrahydroisoquinoline 
• 1604820-82-7 (E)-N-benzyl-N-(2-bromo-4,5-dimethoxybenzyl)-1-(4-methoxyphenyl)-3-(2-styrylphenyl)prop-2-yn-1-amine 
• 1604820-59-8 (E)-2-benzyl-6,7-dimethoxy-3-(4-methoxyphenyl)-4-(2-phenyl-1H-inden-1-ylidene)-1,2,3,4-tetrahydroisoquinoline 
• 1604820-84-9 (E)-N-benzyl-N-(2-bromo-4,5-dimethoxybenzyl)-3-(2-styrylphenyl)prop-2-yn-1-amine 

Relevant academic research and scientific papers

Generation of Donor/Donor Copper Carbenes through Copper-Catalyzed Diyne Cyclization: Enantioselective and Divergent Synthesis of Chiral Polycyclic Pyrroles

The generation of metal carbenes from readily available alkynes represents a significant advance in metal carbene chemistry. However, most of these transformations are based on the use of noble-metal catalysts and successful examples of such an asymmetric version are still very scarce. Here a copper-catalyzed enantioselective cascade cyclization of N-propargyl ynamides is reported, enabling the practical and atom-economical construction of diverse chiral polycyclic pyrroles in generally good to excellent yields with wide substrate scope and excellent enantioselectivities (up to 97:3 e.r.). Importantly, this protocol represents the first copper-catalyzed asymmetric diyne cyclization. Moreover, mechanistic studies revealed that the generation of donor/donor copper carbenes is presumably involved in this 1,5-diyne cyclization, which is distinctively different from the related gold catalysis, and thus it constitutes a novel way for the generation of donor/donor metal carbenes.

De Novo Synthesis of Phenols and Naphthols through Oxidative Cycloaromatization of Dienynes

In this work, a rhodium-catalyzed oxidative cycloaromatization of dienynes, which provides a highly straightforward and efficient way to access polysubstituted naphthols and phenols under mild conditions, is described. Challenged electron-withdrawing groups are well tolerated in this protocol, and late-stage phenyl ring formation is demonstrated.

1,2,3-Triazoles as inhibitors of indoleamine 2,3-dioxygenase 2 (IDO2)

Indoleamine 2,3-dioxygenase 2 (IDO2) is a potential therapeutic target for the treatment of diseases that involve immune escape such as cancer. In contrast to IDO1, only a very limited number of inhibitors have been described for IDO2 due to inherent diff

Photochemistry of chloro-2-vinylstilbenes

Short irradiation at 300 nm of α-chloro- and β-chloro-2-vinylstilbene (20 and 21) leads to a mixture of 2-vinyltolane (35) and 2-vinylstilbene (1) accompanied by the cis- and trans-isomers of the starting compounds.Evidence is found for the occurrence of an ionic intermediate during the photolysis of 20 in methanol.At 360 nm, an additional, small amount of 1-chloro-endo- and 1-chloro-exo-6-phenylbenzobicyclohex-2-ene (39) is formed formed from 20.The elimination of hydrogen chloride also occurs during the irradiation of 2-(2-chlorovinyl)stilbene (23) and leads to 2-ethynylstilbene (41).The acetylenic compounds are photocyclized into 2-phenylnaphthalene (38).However, 2-(1-chlorovinyl)stilbene (22) reacts without loss of chlorine to give 1-chloro-exo-5-phenylbenzobicyclo-hex-2-ene (40).This exceptional reaction mode is due to a much higher rate of photocyclization resulting from less distortion in the stilbene moiety and a preference for a conformation better suited to the reaction of the 2-(1-chlorovinyl)stilbene molecule.It is shown that both isomers of 22 can photocyclize into 40.

The Photochemistry of 2-Vinyldiphenylacetylene and Related Compounds

Irradiation of solutions of 2-vinyldiphenylacetylene (5) under anaerobic conditions gives 2-phenylnaphtalene (9) in 90 percent yield.Several derivatives of (5) behave similarly.The reaction is ascribed to the primary formation of a cyclic allene (29), as has been proposed previously for the analogous photocyclization of 1,4-diarylbutenynes into phenylaromatic compounds.The end-product arises from (29) either via a 1,5-hydrogen shift or by addition and elimination of a proton.Irradiation of 2-ethynylstilbene (21) also yields (9), but 1-ethynylphenanthrene (22) is formed as a side-product.