175405-60-4

Upstream product

• 175405-50-2 2-Ethoxy-[1,3]dioxane-5,5-dicarboxylic acid diethyl ester 
• 175405-51-3 2-Ethoxy-[1,3]dioxane-5,5-dicarboxylic acid bis-[(3-amino-propyl)-amide] 
• 20605-01-0 diethyl bis(hydroxymethyl)malonate 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 175405-54-6 2-Ethoxy-[1,3]dioxane-5,5-dicarboxylic acid bis-{[3-(5-dimethylamino-naphthalene-1-sulfonylamino)-propyl]-amide} 

Relevant academic research and scientific papers

Synthesis of Oligonucleotide Analogues by Using Phosphoramidite Reagents Derived from 2,2-Bis(hydroxymethyl)malonates

A new family of non-nucleosidic phosphoramidite reagents derived from either esters or amides of 2,2-bis(hydroxymethyl)malonic acid is described.The utility of the building blocks 1-5 is demonstrated by preparation of 5'-phosphorylated oligonucleotides as well as hydrophobic, polyamino and fluorescent labelled oligonucleotide analogues.