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20605-01-0 Usage


Diethyl bis(hydroxymethyl)malonate is an organic compound that serves as a versatile reagent and intermediate in the synthesis of various chemical compounds. It is characterized by its ability to facilitate the preparation of 1,3-dioxanes from acetals, aldehydes, and ketones, as well as its role in the production of substituted malonic, acrylic, and isobutyric esters.


Used in Chemical Synthesis:
Diethyl bis(hydroxymethyl)malonate is used as a reagent for preparing 1,3-dioxanes from acetals, aldehydes, and ketones. Its unique properties enable the formation of these important intermediates in organic chemistry, which can be further utilized in the synthesis of a wide range of compounds.
Used in Pharmaceutical Industry:
Diethyl bis(hydroxymethyl)malonate is used as an intermediate for the preparation of substituted malonic, acrylic, and isobutyric esters. These esters are valuable building blocks in the synthesis of various pharmaceutical compounds, contributing to the development of new drugs and therapeutic agents.
Used in Specialty Chemicals:
Diethyl bis(hydroxymethyl)malonate is also used in the conversion to useful dienophiles, such as β-bromomethylacrylic acid and its ethyl ester, as well as bis(bromomethyl)acetic acid and its methyl ester. These dienophiles are important in the field of specialty chemicals, where they can be employed in the synthesis of complex organic molecules with specific properties and applications.

Check Digit Verification of cas no

The CAS Registry Mumber 20605-01-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,6,0 and 5 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 20605-01:
60 % 10 = 0
So 20605-01-0 is a valid CAS Registry Number.

20605-01-0 Well-known Company Product Price

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  • (Code)Product description
  • CAS number
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  • Alfa Aesar

  • (A13677)  Diethyl bis(hydroxymethyl)malonate, 97%   

  • 20605-01-0

  • 25g

  • 615.0CNY

  • Detail
  • Alfa Aesar

  • (A13677)  Diethyl bis(hydroxymethyl)malonate, 97%   

  • 20605-01-0

  • 100g

  • 1636.0CNY

  • Detail
  • Alfa Aesar

  • (A13677)  Diethyl bis(hydroxymethyl)malonate, 97%   

  • 20605-01-0

  • 500g

  • 6092.0CNY

  • Detail
  • Aldrich

  • (198358)  Diethylbis(hydroxymethyl)malonate  97%

  • 20605-01-0

  • 198358-25G

  • 870.48CNY

  • Detail
  • Aldrich

  • (198358)  Diethylbis(hydroxymethyl)malonate  97%

  • 20605-01-0

  • 198358-100G

  • 2,624.31CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017


1.1 GHS Product identifier

Product name diethyl 2,2-bis(hydroxymethyl)propanedioate

1.2 Other means of identification

Product number -
Other names bis(hydroxymethyl)diethylmalonate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:20605-01-0 SDS

20605-01-0Relevant articles and documents

Synthesis, antiproliferative activity and DNA binding study of mixed ammine/cyclohexylamine platinum(II) complexes with 1-(substituted benzyl) azetidine-3, 3-dicarboxylates

Sun, Yanyan,Gou, Shaohua,Yin, Runting,Jiang, Pingyuan

, p. 5146 - 5153 (2011)

A novel series of ammine/cyclohexylamine platinum(II) complexes with 1-(substituted benzyl) azetidine-3, 3-dicarboxylates as leaving groups have been synthesized and characterized. All complexes were characterized by elemental analysis, IR, 1H NMR, and ESI-MS spectra. The in vitro antiproliferative activities of the platinum-based compounds have been investigated against several human cancer cell lines, indicating that complexes 1 and 11 showed comparable cytotoxicity to those of cisplatin and oxaliplatin against four cell lines, superior to that of carboplatin. The results of drug safety evaluation (acute toxicity study) showed that complex 11 was much less toxic than cisplatin and oxaliplatin. Flow cytometry and agarose gel electrophoresis studies revealed that both complexes 1 and 11 induced apoptosis of tumor cells and demonstrated the binding affinity of complexes with pET22b plasmid DNA.

Novel intermediate and improved process for the preparation of iobitridol using thereof


Paragraph 0046; 0084-0086, (2018/04/18)

The present invention relates to a novel method for producing iobitridol represented by chemical formula 1, 1-N,3-N-bis(2,3-dihydroxypropyl)-5-[3-hydroxy-2-(hydroxymethyl)propanamido]-2,4,6-triiodo-1-N,3-N-dimethylbenzene-1,3-dicarboxamide, which is a component for a contrast medium, and novel intermediates for the same. According to the present invention, desired entecavir can be produced economically and easily from the novel intermediates at a high yield.COPYRIGHT KIPO 2018

Synthesis of Panal Terpenoid Core

Baranov, Mikhail S.,Kaskova, Zinaida M.,Gritсenko, Roman,Postikova, Svetlana G.,Ivashkin, Pavel E.,Kislukhin, Alexander A.,Moskvin, Dmitrii I.,Mineev, Konstantin S.,Arseniev, Alexander S.,Labas, Yulii A.,Yampolsky, Ilia V.

supporting information, p. 583 - 588 (2017/03/11)

Panal is a natural bicyclic cadalane-type sesquiterpenoid with an unusual combination of stereocenters. It was isolated in 1988 as an alleged biosynthetic precursor of luciferin (a light-emitting molecule) in a bioluminescent fungus Panellus stipticus. Herein we present the first approach to the synthesis of the terpenoid skeleton of panal, which includes construction of five stereocenters, one of which is easily epimerizable. The key steps in the synthetic approach presented are high-pressure Diels-Alder reaction disobeying the ‘endo rule’, Barbier reductive allylation, and cyclization of trans-decalin ring via ring-closing metathesis.

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