175441-55-1

Upstream product

• 108-24-7 acetic anhydride 
• 175523-43-0 C₃₇H₅₅N₃O₉Si₂ 
• 189190-72-5 13-β-chloro-7-(triethylsilyl)-A-nor-baccatin III 
• 115437-21-3 7-(triethylsilyl)baccatin III 
• 175441-49-3 4-deacetyl-1-dimethylsilyl-7-triethylsilylbaccatin III 
• 175441-47-1 C₄₂H₆₆O₁₁Si₃ 

Downstream Products

• 189190-85-0 C₅₄H₇₂N₂O₁₃Si 

Relevant academic research and scientific papers

Synthesis and biological evaluation of amide-linked A-norpaclitaxels

A novel amide-linked A-norpaclitaxel 3a and two 2-aroyl analogs 3b and 3c were prepared from 10-deacetyl baccatin III. Key steps in the synthesis were the conversion of 7-(triethylsilyl)baccatin m to its 13β-chloro-A-nor derivative 6, reaction with sodium

Synthesis and biological evaluation of C-13 amide-linked paclitaxel (Taxol) analogs

Several C-13 amidopaclitaxel analogs have been synthesized during the course of our structure-activity relationship study at the C-13 position. These include 4-deacetyl-13-amidopaclitaxel (4), 13-amidopaclitaxel 4-(methyl carbonate) derivatives (5a,b), and 13-amidopaclitaxel (6). None of these novel C-13 amidopaclitaxel analogs retain any activity in the tubulin polymerization assay or the in vitro cytotoxicity assay.