175473-92-4Relevant academic research and scientific papers
Development of Bioreduction Labile Protecting Groups for the 2′-Hydroxyl Group of RNA
Nakamura, Kodai,Ono, Akira,Saneyoshi, Hisao,Terasawa, Kazuma
supporting information, (2020/08/05)
Protection and deprotection of the 2′-hydroxyl group of RNAs are critical for RNA-based drug discovery. This paper reports development of a bioreduction labile protecting group of the 2′-hydroxyl group in RNA. After the reduction of the nitro group in a c
Methoxymethyl and (p-nitrobenzyloxy)methyl groups in synthesis of oligoribunucleotides by the phosphotriester method
Efimov,Aralov,Chakhmakhcheva
, p. 254 - 258 (2012/05/20)
An efficient method to synthesize monomer ribonucleotide synthons containing 2′-O-methoxymethyl and 2′-O-(p-nitrobenzyloxy)methyl groups is developed. These synthons are applied to the oligo-nucleotide phosphotriester method using O-nucleophilic intramole
Assessment of 4-nitrogenated benzyloxymethyl groups for 2′-Hydroxyl protection in solid-phase RNA synthesis
Cieslak, Jacek,Kauffman, Jon S.,Kolodziejski, Michelle J.,Lloyd, John R.,Beaucage, Serge L.
, p. 671 - 674 (2008/02/05)
The search for a 2′-OH protecting group that would impart ribonucleoside phosphoramidites with coupling kinetics and coupling efficiencies comparable to those of deoxyribonucleoside phosphoramidites led to an assessment of 2′-0-(4-nitrogenated benzyloxy)m
