1755-98-2Relevant academic research and scientific papers
UREA DERIVATIVES AS PYRUVATE KINASE ACTIVATORS
-
, (2022/02/15)
The subject matter described herein is directed to pyruvate kinase activating compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for the treatment of diseases associated with PKR and/or PKM2, such as pyruvate kinase deficiency, sickle cell disease, and beta-thalassemia.
HETEROCYCLIC COMPOUNDS AND USE THEREOF
-
Page/Page column 34, (2018/08/03)
Heterocyclic compounds of Formula (I) shown herein. Also disclosed is a pharmaceutical composition containing one of the heterocyclic compounds. Further disclosed are methods of using one of the heterocyclic compounds for mobilizing hematopoietic stem cells and endothelial progenitor cells into the peripheral circulation, and for treating tissue injury, cancer, inflammatory disease, and autoimmune disease.
Inverse Electron Demand Diels-Alder Reactions of Indole IV. A New Route to β-Carbolines
Fan, Wen-Hong,Parikh, Mamta,Snyder, John K.
, p. 6591 - 6594 (2007/10/02)
β-Carbolines have been prepared by the intramolecular cycloaddition of indole with 1,2,4-triazines tethered from C3 with the indolyl nitrogen using a thiourea linkage.Subsequent to the cycloaddition, reductive cleavage of the thiourea subunit provides the β-carboline.
