91641-80-4Relevant academic research and scientific papers
Synthesis and Properties of &α-Aminocarbohydroximic Esters
Thimann, Wolfgang,Geffken, Detlef
, p. 547 - 553 (2007/10/03)
Cbz protected α-aminonitriles 1 or α-aminocarboxamides 2 were converted to imidates 3 either by Pinner reaction or by Meerwein's reagent. Sulfhydrolysis of 3 produced α-aminothiocarboxylic O-esters 4 which in turn were reacted with hydroxylamine to give C
Dithio and Thiono Esters, 55. - Synthesis of N-Protected, Optically Active α-Amino Thiono Esters
Brutsche, Andreas,Hartke, Klaus
, p. 921 - 926 (2007/10/02)
The N-protected α-amino amides 1 are O-alkylated with trialkyloxonium tetrafluoroborates to form the iminium salts 2.Sulfhydrolysis of 2 yields the α-amino thiono esters 3.This reaction sequence allows the preparation of enantiomerically pure 3.Key Words:
Studies on Amino Acids and Peptides. Part 6. Methods for Introducing Thioamide Bonds into the Peptide Backbone: Synthesis of the Four Monothio Analogues of Leucine Enkephalin
Clausen, Kim,Thorsen, Michael,Lawesson, Sven-Olov,Spatola, Arno F.
, p. 785 - 798 (2007/10/02)
A methodology for preparing peptide analogues in which a thioamide bond replaces the normal amide bond is described.Thus, the synthesis of the three leucine enkephalin analogues 4>-, 2>-, and 1>-leucine enke
