175531-38-1Relevant articles and documents
Small-Molecule Inhibition of the C. difficile FAS-II Enzyme, FabK, Results in Selective Activity
Jones, Jesse A.,Prior, Allan M.,Marreddy, Ravi K. R.,Wahrmund, Rebecca D.,Hurdle, Julian G.,Sun, Dianqing,Hevener, Kirk E.
, p. 1528 - 1535 (2019/07/09)
Clostridioides difficile infection (CDI) is a leading cause of significant morbidity, mortality, and healthcare-related costs in the United States. After standard therapy, recurrence rates remain high, and multiple recurrences are not uncommon. Causes inc
Synthesis and antiplasmodial activity of new heteroaryl derivatives of 7-chloro-4-aminoquinoline
Casagrande, Manolo,Barteselli, Anna,Basilico, Nicoletta,Parapini, Silvia,Taramelli, Donatella,Sparatore, Anna
, p. 5965 - 5979 (2012/10/29)
With the aim to investigate the effect of different heterocyclic rings linked to the 4-aminoquinoline nucleus on the antimalarial activity, a set of 7-chloro-N-(heteroaryl)-methyl-4-aminoquinoline and 7-chloro-N-(heteroaryl)-4- aminoquinoline was synthesi
Derivatives of heterocycles with 5 members, their preparation and their use as medicaments
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, (2008/06/13)
The invention relates to thiazole, oxazole, imidazole, isoxazole and isoxazoline derivatives of general formula (I) wherein Het is thiazole, oxazole, imidazole, isoxazole or isoxazoline, n is an integer from 0 to 6, A is notably selected from various optionally substituted aromatic radicals, B is notably hydrogen, alkyl or phenyl, R1 and R2 are notably independently hydrogen, alkyl or cycloalkyl or R1 and R2, taken together with the carbon atom which carries them, form a carbocycle with 3 to 7 members and Ω is —NR46R47 or —OR48, R46 and R47 are notably independently hydrogen, alkyl, cycloalkyl or —(CH2)k—COOR51, R51 is notably alkyl or haloalkyl and R48 is notably hydrogen or alkyl. These compounds have advantageous pharmacological properties which allow their use in therapeutics, notably for treating neurodegenerative disorders or pain.