335243-57-7

Upstream product

• 4530-20-5 BOC-glycine 
• 83316-95-4 2-oxo-2-phenylethyl 2-(tert-butoxycarbonylamino)acetate 

Downstream Products

• 175531-38-1 (4-phenyl-1H-imidazol-2-yl)methanamine 
• 1404113-46-7 tert-butoxycarbonyl (1-methyl-4-phenyl-1H-imidazol-2-yl)methylamine 
• 1404112-73-7 C₁₉H₁₅ClN₄ 
• 1404113-47-8 (1-methyl-4-phenyl-1H-imidazol-2-yl)methanamine 
• 1404112-86-2 C₂₀H₁₇ClN₄ 
• 1404112-98-6 C₂₅H₂₆ClN₅ 
• 1404112-91-9 C₂₄H₂₄ClN₅ 
• 1404113-60-5 C₂₄H₂₆ClN₅ 

Relevant academic research and scientific papers

Synthesis and antiplasmodial activity of new heteroaryl derivatives of 7-chloro-4-aminoquinoline

With the aim to investigate the effect of different heterocyclic rings linked to the 4-aminoquinoline nucleus on the antimalarial activity, a set of 7-chloro-N-(heteroaryl)-methyl-4-aminoquinoline and 7-chloro-N-(heteroaryl)-4- aminoquinoline was synthesi

Role of benzimidazole (Bid) in the δ-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH2-Bid (UFP-502)

H-Dmt-Tic-NH-CH2-Bid (UFP-502) was the first δ-opioid agonist prepared from the Dmt-Tic pharmacophore. It showed interesting pharmacological properties, such as stimulation of mRNA BDNF expression and antidepression. To evaluate the importance of 1H-benzimidazol-2-yl (Bid) in the induction of δ-agonism, it was substituted by similar heterocycles: The substitution of NH(1) by O or S transforms the reference δ-agonist into δ-antagonists. Phenyl ring of benzimidazole is not important for δ-agonism; in fact 1H-imidazole-2-yl retains δ-agonist activity.