17559-65-8Relevant academic research and scientific papers
2,5-Bis(piperidinomethyl)pyrrole and (2,5-Pyrrolediyldimethylene)bis(triphenylphosphoniumiodide): Synthesis and Reactions Leading to (2,5)Pyrrolophanes and 2,5-Bisvinyl-substituted Pyrroles
Flitsch, Wilhelm,Kneip, Heinz-Gerd
, p. 1895 - 1903 (2007/10/02)
Mannich reaction of pyrrole results in the formation of 2,5-bis(piperidinomethyl)pyrrole (1a) which, after quaternization and treatment with cyanide, yields the stereoisomeric (2,5)pyrrolophanes 3a-c and 2,5-bis(cyanomethyl)pyrrole (1c). (2,5-Pyrrolediyldimethylene)bis(triphenylphosphonium iodide) (5a) and (2-pyrrolylmethyl)triphenylphosphonium iodide (8c) are obtained from the methiodides of 1a and 2-(dimethylaminomethyl)pyrrole (8a), respectively.They undergo Wittig reaction with aldehydes, but predominantly form substitution products if nucleophiles are present.
