99230-18-9Relevant academic research and scientific papers
AMINO ALCOHOL DERIVATIVE OR PHOSPHONIC ACID DERIVATIVE AND MEDICINAL COMPOSITION CONTAINING THESE
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Page 305, (2008/06/13)
The present invention relates to amino alcohol derivatives or phosphonic acid derivatives having excellent immunosuppressive activity, pharmacologically acceptable salts thereof or pharmacologically acceptable esters thereof, and to pharmaceutical compositions comprising said compounds as an active ingredient: [wherein, ???R1 and R2 each represent a hydrogen atom, or a protecting group of the amino group; ???R3 represents a hydrogen atom, or a protecting group of the hydroxyl group; ???R4 represents a lower alkyl group; ???n represents an integer of from 1 to 6; ???X represents an oxygen atom or a nitrogen atom unsubstituted or substituted with a lower alkyl group or the like; ???Y represents an ethylene group; ???Z represents a C1-C10 alkylene group; ???R5 represents an aryl group, or an aryl group substituted with substituents; ???R6 and R7 each represents a hydrogen atom; provided that when R5 represents a hydrogen atom, then Z represents a group other than a single bond or a straight chain C1-C10 alkylene group] .
2,5-Bis(piperidinomethyl)pyrrole and (2,5-Pyrrolediyldimethylene)bis(triphenylphosphoniumiodide): Synthesis and Reactions Leading to (2,5)Pyrrolophanes and 2,5-Bisvinyl-substituted Pyrroles
Flitsch, Wilhelm,Kneip, Heinz-Gerd
, p. 1895 - 1903 (2007/10/02)
Mannich reaction of pyrrole results in the formation of 2,5-bis(piperidinomethyl)pyrrole (1a) which, after quaternization and treatment with cyanide, yields the stereoisomeric (2,5)pyrrolophanes 3a-c and 2,5-bis(cyanomethyl)pyrrole (1c). (2,5-Pyrrolediyldimethylene)bis(triphenylphosphonium iodide) (5a) and (2-pyrrolylmethyl)triphenylphosphonium iodide (8c) are obtained from the methiodides of 1a and 2-(dimethylaminomethyl)pyrrole (8a), respectively.They undergo Wittig reaction with aldehydes, but predominantly form substitution products if nucleophiles are present.
