175609-69-5Relevant academic research and scientific papers
Versatile 2-fluoroacrylic building blocks for the synthesis of fluorinated heterocyclic compounds
Shi, Guo-Qiang,Wang, Qian,Schlosser, Manfred
, p. 4403 - 4410 (2007/10/03)
The methyl ester of 2-fluoro-3-methoxyacrylic acid and the corresponding acyl chloride can be used for the efficacious synthesis of fluorine bearing pyrazolones, pyrimidines, coumarines and benzothiopyranones. Depending on the C3F component and the conditions employed, the same cyclization partner (e.g., 2-aminothiophenol) may lead to two or even three different products.
Metalated Fluoropyridines and Fluoroquinolines as Reactive Intermediates: New Ways for Their Regioselective Generation
Shi, Guo-qiang,Takagishi, Sadahito,Schlosser, Manfred
, p. 1129 - 1134 (2007/10/02)
The mixture of lithium diisopropylamide and potassium tert-butoxide ("LIDA-KOR reagent") is a powerful base which can be advantageously employed for the regioselective deprotonation of fluoropyridines and, in particular, 3-fluoroquinoline.A novel cyclization process was elaborated for the preparation of the latter product.
