175609-70-8

Usage

Physical State

Colorless to light yellow liquid

Common Uses

Synthesis of pharmaceuticals and organic compounds, flavoring agent

Aroma

Sweet, floral, and spicy

Configuration

(Z)configuration indicates substituents on the double bond are on the same side, leading to specific stereochemistry

Potential Applications

Development of new drugs and agrochemicals

Safety Precautions

Should be handled with care; may be harmful if ingested, inhaled, or in contact with the skin

Upstream product

• 75-43-4 Dichlorofluoromethane 
• 96488-40-3 [[1,2-dimethoxyethenyl]oxy]trimethylsilane 
• 175609-69-5 (Z/E)-methyl 2-fluoro-3-methoxyprop-2-enoate 

Relevant academic research and scientific papers

Versatile 2-fluoroacrylic building blocks for the synthesis of fluorinated heterocyclic compounds

The methyl ester of 2-fluoro-3-methoxyacrylic acid and the corresponding acyl chloride can be used for the efficacious synthesis of fluorine bearing pyrazolones, pyrimidines, coumarines and benzothiopyranones. Depending on the C3F component and the conditions employed, the same cyclization partner (e.g., 2-aminothiophenol) may lead to two or even three different products.

Metalated Fluoropyridines and Fluoroquinolines as Reactive Intermediates: New Ways for Their Regioselective Generation

The mixture of lithium diisopropylamide and potassium tert-butoxide ("LIDA-KOR reagent") is a powerful base which can be advantageously employed for the regioselective deprotonation of fluoropyridines and, in particular, 3-fluoroquinoline.A novel cyclization process was elaborated for the preparation of the latter product.