175650-34-7

Upstream product

• 729-81-7 1,3,5-tris(trifluoromethyl)benzene 
• 71-43-2 benzene 
• 402-31-3 1,3-bis(trifluoromethyl)benzene 
• 119-61-9 benzophenone 
• 328-70-1 3,6-bis(trifluoromethyl)bromobenzene 

Downstream Products

• 1055316-01-2 [(Et₃P)2Rh(OC(3,5-(CF₃)2C₆H₃)Ph₂)] 
• 119-61-9 benzophenone 
• 21221-93-2 [3,5-bis(trifluoromethyl)phenyl](phenyl)methanone 

Relevant academic research and scientific papers

1-bromo-3,5-bis(trifhioromethyl)benzene: A versatile starting material for organometallic synthesis

1-Bromo-3,5-bis(trifluoromethyl)benzene (1) can be selectively prepared by treatment of 1,3-bis(fluorornethyl)benzene with N,N′-dibromo-5,5-dimethylhydantoin in strongly acidic media. A number of synthetically useful reactions via 3,5bis{trifluoromethyl)phenylmagnesium, -lithium, and -copper intermediates were accomplished. VCH Verlagsgesellschaft mbH, , 1996.

Protolytic defluorination of trifluoromethyl-substituted arenes

A series of trifluoromethyl-substituted arenes were studied in their reactions with Bronsted superacids. The products from these reactions suggest the formation of reactive electrophiles, such as carbocations, acylium cations or equivalent electrophilic species. As such, Friedel-Crafts-type reactions occur between these species and arene nucleophiles. NMR studies were done, and the results suggest the formation of an acyl group from the trifluoromethyl groups in the superacid.