175655-11-5Relevant articles and documents
Pyridinium lodochloride: An efficient reagent for lodination of hydroxylated aromatic ketones and aldehydes
Khansole, Sandeep V.,Mokle, Shyam S.,Sayyed, Mudassar A.,Vibhute, Yeshwant B.
, p. 871 - 874 (2008)
Direct iodination of several reactive aromatic compounds like hydroxy substituted acetophenones and aldehydes with pyridinium iodochloride (PyICl) proceeded smoothly to afford the corresponding aromatic iodides in good to excellent yield. Pyridinium iodochloride has been found to be an efficient solid iodinating reagent with no hazardous effect and it can be handled safely.
Design, synthesis and biological studies of Survivin Dimerization Modulators that prolong mitotic cycle
Chettiar, Somsundaram N.,Cooley, James V.,Park, In-Hee,Bhasin, Deepak,Chakravarti, Arnab,Li, Pui-Kai,Li, Chenglong,Jacob, Naduparambil Korah
supporting information, p. 5429 - 5433 (2013/09/23)
Survivin, a member of the inhibitor of apoptosis protein (IAP) family proteins, has essential roles in cell division and inhibition of apoptosis. Several clinical studies in cancer patients have shown that the elevated levels of survivin correlate with aggressiveness of the disease and resistance to radiation and chemotherapeutic treatments. Survivin is an integral component of chromosomal passenger complex (CPC) where it binds to borealin and INCENP through its dimerization interface. Thus, disruption of functional survivin along its dimer interface with a small molecule is hypothesized to inhibit the proliferation of cancer cells and sensitize them to therapeutic agents and radiation. Recently, a small molecule (Abbott8) was reported to bind at the dimerization interface of survivin. Further development of this compound was accomplished by computational modeling of the molecular interactions along the dimerization interface, which has led to the design of promising survivin dimerization modulators. Two of the most potent survivin modulators, LLP3 and LLP9 at concentrations between 50 and 100 nM, caused delay in mitotic progression and major mitotic defects in proliferating human umbilical vein endothelial cells (HUVEC) and prostate cancer cells (PC3).
A simple and efficient method for solvent-free iodination of hydroxylated aromatic aldehydes and ketones using iodine and iodic acid by grinding method
Vibhute, Archana,Mokle, Shyam,Karamunge, Khushal,Gurav, Vasant,Vibhute, Yeshwant
experimental part, p. 914 - 918 (2011/11/12)
Green, mild and efficient iodination of hydroxylated aromatic aldehydes and ketones using iodine and iodic acid in the solid-state by grinding under solvent-free conditions at room temperature. This method provides several advantages such as environmentally friendly, short reaction times, high yields, non-hazardous and simple work-up procedure.
A practical iodination of aromatic compounds by using iodine and iodic acid
Shinde, Avinash T.,Zangade, Sainath B.,Chavan, Shivaji B.,Vibhute, Archana Y.,Nalwar, Yogesh S.,Vibhute, Yeshwant B.
experimental part, p. 3506 - 3513 (2011/02/22)
This article describes simple and efficient method for the iodination of different aromatic amines, hydroxy aromatic aldehydes, hydroxy acetophenones and phenols using iodine and iodic acid in ethanol as a solvent. Notable advantages include mild reaction condition, no need of catalyst, short reaction time, simple practical procedure, giving excellent yield of the product. Copyright Taylor & Francis Group, LLC.
Synthesis of new hydroxyacetophenones by using iodine and iodic acid
Dawane,Vibhute
, p. 299 - 299 (2007/10/03)
Iodine and iodic acid mixture has been used as a reagent for iodination of hydroxyacetophenones, and some new hydroxyiodoacetophenones are prepared.
