175656-27-6

Upstream product

• 75-65-0 tert-butyl alcohol 
• 175656-24-3 (S)-3-{(2R,3R)-2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-ethyl-5-trimethylsilanyl-pent-4-ynoyl}-4-isopropyl-oxazolidin-2-one 
• 175656-26-5 (2R,3R)-2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-ethyl-pent-4-ynoic acid 

Downstream Products

• 1026837-32-0 (2R,3R)-3-Amino-5-(tert-butyl-diphenyl-silanyloxy)-2-ethyl-pentanoic acid 
• 115946-44-6 (3R,4R)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-ethyl-azetidin-2-one 
• 175656-28-7 (2R,3R)-3-tert-Butoxycarbonylamino-5-(tert-butyl-diphenyl-silanyloxy)-2-ethyl-pentanoic acid 

Relevant academic research and scientific papers

Formal total syntheses of the β-lactam antibiotics thienamycin and PS-5

Chiral nonracemic acetylenic acids of general structure 11, prepared using the Schreiber modification of the Nicholas reaction, have been converted to β-amino acid derivatives of type 12 by a two-step sequence involving Curtius rearrangement followed by o