175657-37-1

Upstream product

• 5000-66-8 2-chlorophenacyl bromide 
• 507-09-5 tiolacetic acid 
• 10387-40-3 potassium thioacetate 

Downstream Products

• 595565-59-6 2'-chloro-2-thioacetophenone 
• 175657-49-5 5-(2-Chloro-benzoyl)-4-hydroxy-thiophene-2-carboxylic acid 
• 175657-42-8 5-(2-Chloro-benzoyl)-4-hydroxy-thiophene-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Bicyclic pyridine and pyrimidine p38 kinase inhibitors

The present invention discloses compounds corresponding to formula wherein A, R, X, Y, R, R1 and R2 are as defined above, pharmaceutical formulations, methods of making and uses thereof.

A synthesis of 2-acyl-3-hydroxythiophenes

2-Acyl-3-hydroxythiophenes have been made by the reaction of the anion of a mercaptoketone with dimethyl acetylenedicarboxylate to give a hydroxythiophene ester which is then hydrolysed and decarboxylated.