175691-91-5

Basic information

• Product Name: BIPHENYL-3-CARBOTHIOIC ACID AMIDE
• Synonyms: BIPHENYL-3-CARBOTHIOIC ACID AMIDE
• CAS NO: 175691-91-5
• Molecular Formula: C13H11NS
• Molecular Weight: 213.3
• Mol File: 175691-91-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BIPHENYL-3-CARBOTHIOIC ACID AMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: BIPHENYL-3-CARBOTHIOIC ACID AMIDE(175691-91-5)
• EPA Substance Registry System: BIPHENYL-3-CARBOTHIOIC ACID AMIDE(175691-91-5)

Safety Data

• Hazardous Substances Data: 175691-91-5(Hazardous Substances Data)

Usage

General Description

Biphenyl-3-carbothioic acid amide is a chemical compound commonly used as a coupling agent in organic synthesis and as a building block in the production of pharmaceuticals and agrochemicals. It is also utilized in the development of materials such as liquid crystals and polymers. This chemical possesses unique properties that make it suitable for various applications such as anti-corrosion coatings, flame retardants, and UV stabilizers. Additionally, it can be used in the synthesis of dyes and pigments due to its ability to create strong chemical bonds with other compounds. Overall, biphenyl-3-carbothioic acid amide is a versatile chemical with a wide range of industrial and commercial uses.

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Relevant articles and documents

Syntheses and selective inhibitory activities of terphenyl-bisamidines for serine proteases

Biphenyl nitriles 5a-c, terphenyl dinitriles 11a-d, and naphthalene-bis(benzonitrile) 11e were prepared by palladium-catalyzed cross coupling reactions and subsequently converted to biphenyl amidines 8a-c and bis(benzamidines) 4a-e. Among the biphenyl amidines 8 only the meta-derivative 8b inhibits factor Xa and trypsin (K(i) = 10 μM). The terphenyl bisamidine 4c does not inhibit factor Xa, trypsin, thrombin, and plasmin, while 4a and 4d are almost equipotent inhibitors of theses enzymes (K(i) 1-6 μM), and 4b and 4e are selective for trypsin (K(i) = 0.2 and 0.3 μM; but K(i) > 1 μM for factor Xa, thrombin, and plasmin). X-ray analysis of crystals of 4b complexed with bovine trypsin revealed a unique binding mode: one benzamidino group binds in the S1 site to the side chain carboxylate of Arg 189. The central phenyl group is twisted away from the S2/S3 sites and the second amidino group contacts the Asn 143 side chain.