175694-24-3Relevant academic research and scientific papers
Design, synthesis and X-ray crystallographic studies of [7.3.1] and [8.3.1] macrocyclic FKBP-12 ligands
Babine, Robert E.,Bleckman,Littlefield, Ethel S.,Parge, Hans E.,Pelletier,Lewis, Cristina T.,French, Judy V.,Imbacuan, Michael,Katoh, Susumo,Tatlock, John H.,Showalter, Richard E.,Villafranca, J. Ernest
, p. 385 - 390 (2007/10/03)
The design, synthesis, and structure activity relationships of a series of novel macrocyclic FKBP-12 ligands 1 are reported. The crystal structure of the complex between 7 and human FKBP-12 is reported and some SAR results are discussed based on this complex.
