175695-30-4

Upstream product

• 149411-94-9 2-(2-amino-6-(benzyloxy)-9H-purin-9-yl)acetic acid 
• 66224-66-6 adenine 
• 10310-21-1 2-Amino-6-chloropurin 
• 149376-70-5 2-amino-6-chloro-9-carboxymethylpurine 
• 100-51-6 benzyl alcohol 
• 175695-26-8 C₃₂H₄₁N₇O₉ 
• 175695-31-5 methyl 2-{6-[bis(tert-butoxycarbonyl)amino]-9H-purin-9-yl}acetate 
• 175695-25-7 ethyl [N⁶,N⁶-bis(tert-butoxycarbonyl)adenin-9-yl]acetic acid 
• 175695-32-6 tert-butyl (6-chloro-2-aminopurin-9-yl)ethanoate 
• 23124-10-9 2-(N₉-adeninyl)acetic acid methyl ester 
• 175695-28-0 C₃₄H₄₇N₉O₁₀ 
• 175695-22-4 C₂₉H₃₇N₇O₉ 
• 175695-29-1 C₄₈H₅₈N₁₄O₁₂ 

Relevant academic research and scientific papers

Liquid-phase synthesis of polyamide nucleic acids (PNA)

Three liquid-phase processes for the elaboration of short orthogonally protected PNA have been devised. Two of these methods are similar to the convergent and divergent approaches in peptide synthesis. The third process consists in building a fully protected polyamide backbone, by using as many different and orthogonal protecting groups as there are different types of nucleic bases in the targeted polyPNA. Simultaneous and selective cleavage of one kind of protecting group allows the simultaneous attachment of several identical nucleobase units.

Liquid phase synthesis of a peptidic nucleic acid dimer

The first liquid phase synthesis of a peptidic nucleic acid (PNA) dimer containing guanine and adenine has been achieved in good yields. A new strategy was elaborated in order to circumvent difficult coupling of the protected PNA.