175696-73-8

Basic information

• Product Name: 3-PYRROLIDIN-1-YLBENZONITRILE
• Synonyms: 3-PYRROLIDIN-1-YLBENZONITRILE;3-Pyrrolidin-1-ylbenzonitrile 95%
• CAS NO: 175696-73-8
• Molecular Formula: C₁₁H₁₂N₂
• Molecular Weight: 172.23
• Mol File: 175696-73-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 84 °C
• Boiling Point: 316.8 °C at 760 mmHg
• Flash Point: 139 °C
• Appearance: /
• Density: 1.12 g/cm³
• Vapor Pressure: 0.000401mmHg at 25°C
• Refractive Index: 1.588
• CAS DataBase Reference: 3-PYRROLIDIN-1-YLBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PYRROLIDIN-1-YLBENZONITRILE(175696-73-8)
• EPA Substance Registry System: 3-PYRROLIDIN-1-YLBENZONITRILE(175696-73-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 175696-73-8(Hazardous Substances Data)

Usage

General Description

3-Pyrrolidin-1-ylbenzonitrile, also known as PB-22, is a synthetic cannabinoid that belongs to the group of research chemicals known as designer drugs. It is a potent agonist of the cannabinoid receptors CB1 and CB2, which are responsible for the psychoactive effects of cannabis. PB-22 is a highly potent and selective agonist of the CB2 receptor, which makes it a valuable tool for studying the physiological and pharmacological effects of cannabinoids. However, it is not intended for human consumption and has been classified as a controlled substance in some jurisdictions due to its potential for abuse and dependence. Its use has been associated with adverse effects such as anxiety, paranoia, and hallucinations, and further research is needed to fully understand its long-term effects on human health.

InChI:InChI=1/C11H12N2/c12-9-10-4-3-5-11(8-10)13-6-1-2-7-13/h3-5,8H,1-2,6-7H2

Upstream product

• 123-75-1 pyrrolidine 
• 250681-85-7 N-(3-amino-4-methylphenyl)-3-pyrrolidin-1-ylbenzamide 
• 403-54-3 m-Fluorobenzonitrile 
• 766-84-7 3-chloro-benzonitrile 
• 110-52-1 1,4-dibromo-butane 
• 2237-30-1 m-cyanoaniline 

Downstream Products

• 1590397-58-2 2-(4-fluoro-N-isopropylphenylsulfonamido)-N-(3-(pyrrolidin-1-yl)benzyl)acetamide 
• 175696-70-5 (3-(pyrrolidin-1-yl)phenyl)methanamine 

Relevant articles and documents

SUBSTITUTED SULFONAMIDE COMPOUNDS

The invention is concerned with the compounds of formula (I), and salts thereof, wherein X, Y, Z, R1, R2, R3, R3, R4, R5 and R6 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of Formula (I) as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

Simple, efficient catalyst system for the palladium-catalyzed amination of aryl chlorides, bromides, and triflates

Palladium complexes supported by (o-biphenyl)P(t-Bu)2 (3) or (o- biphenyl)PCy2 (4) are efficient catalysts for the catalytic amination of a wide variety of aryl halides and triflates. Use of ligand 3 allows for the room-temperature catalytic amination of many aryl chloride, bromide, and triflate substrates, while ligand 4 is effective for the amination of functionalized substrates or reactions of acyclic secondary amines. The catalysts perform well for a large number of different substrate combinations at 80-110 °C, including chloropyridines and functionalized aryl halides and triflates using 0.5-1.0 mol % Pd; some reactions proceed efficiently at low catalyst levels (0.05 mol % Pd). These ligands are effective for almost all substrate combinations that have been previously reported with various other ligands, and they represent the most generally effective catalyst system reported to date. Ligands 3 and 4 are air-stable, crystalline solids that are commercially available. Their effectiveness is believed to be due to a combination of steric and electronic properties that promote oxidative addition, Pd-N bond formation, and reductive elimination.

The antiinfluenza activity of pyrrolo[2,3-d]pyrimidines

From a group of pyrrolo[2,3-d]pyrimidine compounds that have been screened against influenza virus, one derivative, 4-(3-piperidinyl benzylamino)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine (9), has shown promising activity against both the A and B strains. The