1757-28-4Relevant academic research and scientific papers
Unprecedented α-substituted BOPHY dyes via a key 3,8-dichloroBOPHY intermediate
Boodts, Stijn,Hofkens, Johan,Dehaen, Wim
, p. 249 - 254 (2017)
We present a high-yielding synthesis for 3,8-dichloroBOPHY. Starting from unsubstituted pyrrole, this α-halogenated fluorophore was obtained in 51% yield. Subsequent functionalization via nucleophilic substitutions with O, N and S-nucleophiles was achieve
TAMBJAMINES AND B-RING FUNCTIONALIZED PRODIGININES
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Page/Page column 18; 28; 29, (2016/11/17)
Embodiments of tambjamines and B-ring functionalized prodiginines are disclosed. Methods of synthesizing and using the disclosed compounds are also disclosed. Some embodiments of the disclosed compounds have antimalarial activity. Certain embodiments of t
Synthesis and Structure-Activity Relationships of Tambjamines and B-Ring Functionalized Prodiginines as Potent Antimalarials
Kancharla, Papireddy,Kelly, Jane Xu,Reynolds, Kevin A.
, p. 7286 - 7309 (2015/10/05)
Synthesis and antimalarial activity of 94 novel bipyrrole tambjamines (TAs) and a library of B-ring functionalized tripyrrole prodiginines (PGs) against a panel of Plasmodium falciparum strains are described. The activity and structure-activity relationsh
2- and 3-monohalogenated BODIPY dyes and their functionalized analogues: Synthesis and spectroscopy
Leen, Volker,Leemans, Tom,Boens, Noel,Dehaen, Wim
experimental part, p. 4386 - 4396 (2011/10/04)
Starting from appropriately halogenated acylpyrroles, a wide range of reactive 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) derivatives can be obtained. The fluorescent dyes display excellent reactivity in nucleophilic aromatic substitution, transi
Vilsmeier-Haack reaction with succinamidals. A convenient synthesis of 5-chloropyrrole-2-carboxaldehydes and 5-chloropyrrole-2,4-dicarboxaldehydes
Guzman, Angel,Romero, Moises,Muchowski, Joseph M.
, p. 791 - 794 (2007/10/02)
It is shown that the reaction of N-alkylsuccinamidals (2) with Vilsmeier-Haack reagent derived from DMF and phosphorus oxychloride can be controlled to preferentially produce either 5-chloropyrrole-2-carboxaldehydes (8) or 5-chloropyrrole-2,4-dicarboxalde
