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Usage

Uses

Used in Pharmaceutical Industry:
2-Chloropyrrole is used as a chemical intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Chloropyrrole is utilized as a precursor in the production of pesticides and other agrochemicals, aiding in the creation of compounds that protect crops and enhance agricultural productivity.
Used in Material Science:
2-Chloropyrrole is employed in material science research for its potential applications in developing new materials with specific properties, such as improved conductivity or stability.
Used in Organic Synthesis:
As a building block in organic synthesis, 2-Chloropyrrole is used to construct a variety of organic compounds for diverse applications, including the production of dyes, polymers, and other specialty chemicals.

Upstream product

• 109-97-7 pyrrole 
• 80263-41-8 1-chloro-1H-pyrrole 
• 7791-25-5 sulfuryl dichloride 

Downstream Products

• 142231-06-9 2-benzoyl-5-chloropyrrole 
• 1757-28-4 5-chloro-1H-pyrrole-2-carboxaldehyde 

Relevant academic research and scientific papers

2- and 3-monohalogenated BODIPY dyes and their functionalized analogues: Synthesis and spectroscopy

Starting from appropriately halogenated acylpyrroles, a wide range of reactive 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) derivatives can be obtained. The fluorescent dyes display excellent reactivity in nucleophilic aromatic substitution, transi

A versatile, modular synthesis of monofunctionalized BODIPY dyes

A careful choice of the pyrrole building blocks allows the synthesis of a wide range of monohalogenated BODIPY dyes with excellent reactivity in palladium catalyzed coupling reactions. The Royal Society of Chemistry 2009.

LEWIS ACID CATALYZED HALOGENATION OF ACTIVATED CARBON ATOMS

A practical and efficient method for halogenation of activated carbon atoms using readily available /V-haloimides and a Lewis acid catalyst has been disclosed. This methodology is applicable to a range of compounds and any halogen atom can be directly introduced to the substrate. The mild reaction conditions, easy workup procedure and simple operation make this method valuable from both an environmental and preparative point of view.

Lewis acid catalyzed highly selective halogenation of aromatic compounds

A simple and efficient procedure for the halogenation of aromatic compounds with NCS, NBS, NIS and NFSI in the presence of catalytic amount of ZrCl 4 is described. Chlorination, bromination, iodination and fluorination of various aromatic compounds are performed with high selectivity under mild reaction conditions. Georg Thieme Verlag Stuttgart.

Chlorination of Pyrrole. N-Chloropyrrole: Formation and Rearrangement to 2- and 3-Chloropyrrole

N-Chloropyrrole (2) was formed in 65-72percent yield when pyrrole (1) in CCl4 was chlorinated with aqueous NaOCl.This intermediate rearranged in methanol to give chloropyrroles by two distinct reactions: a thermal rearrangement which gave 2-chloropyrrole (3) and an acid-catalyzed intermolecular reaction which gave 2-chloropyrrole (3), 3-chloropyrrole (4), and 2,5-dichloropyrrole (5).Nucleophilic attack on the N-Cl bond of 2 was demonstrated by reactions in the presence of CN- and SCN-.In the latter case, 2-(thiocyano)pyrrole was formed.

Acid Catalyzed Chlorination of Pyrrole With N-Chloroacetanilide

The chlorination of pyrrole with N-chloroacetanilide was catalyzed by acetic acid.Transfer of Cl+ occurred directly to the α and β positions of pyrrole and a mixture of 2-chloro-, 3-chloro- and 2,5-dichloropyrrole was formed.The α/β ratio was 10:1 under competitive conditions.