56454-22-9

Basic information

• Product Name: 2-Chloropyrrole
• Synonyms: 2-chloro-1H-pyrrole
• CAS NO: 56454-22-9
• Molecular Formula: C₄H₄ClN
• Molecular Weight: 101.5343
• Product Categories: Benzenes
• Mol File: 56454-22-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 79-81 °C
• Boiling Point: 181.225 °C at 760 mmHg
• Flash Point: 79.106 °C
• Appearance: /
• Density: 1.274 g/cm³
• PKA: 16.02±0.50(Predicted)
• CAS DataBase Reference: 2-Chloropyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloropyrrole(56454-22-9)
• EPA Substance Registry System: 2-Chloropyrrole(56454-22-9)

Safety Data

• Hazardous Substances Data: 56454-22-9(Hazardous Substances Data)

Usage

General Description

2-Chloropyrrole is a chemical compound that consists of a pyrrole ring with a chlorine atom attached to it at the 2-position. It is a heterocyclic organic compound and is commonly used as a precursor in the synthesis of various pharmaceuticals and agrochemicals. 2-Chloropyrrole has also been studied for its potential application in material science and as a building block in the synthesis of organic compounds. It is important to note that 2-Chloropyrrole should be handled with care as it is a potentially hazardous chemical, and appropriate safety measures should be taken when working with it.

Upstream product

• 109-97-7 pyrrole 
• 7791-25-5 sulfuryl dichloride 
• 80263-41-8 1-chloro-1H-pyrrole 

Downstream Products

• 1757-28-4 5-chloro-1H-pyrrole-2-carboxaldehyde 
• 142231-06-9 2-benzoyl-5-chloropyrrole 

Relevant articles and documents

2- and 3-monohalogenated BODIPY dyes and their functionalized analogues: Synthesis and spectroscopy

Starting from appropriately halogenated acylpyrroles, a wide range of reactive 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) derivatives can be obtained. The fluorescent dyes display excellent reactivity in nucleophilic aromatic substitution, transi

LEWIS ACID CATALYZED HALOGENATION OF ACTIVATED CARBON ATOMS

A practical and efficient method for halogenation of activated carbon atoms using readily available /V-haloimides and a Lewis acid catalyst has been disclosed. This methodology is applicable to a range of compounds and any halogen atom can be directly introduced to the substrate. The mild reaction conditions, easy workup procedure and simple operation make this method valuable from both an environmental and preparative point of view.

Chlorination of Pyrrole. N-Chloropyrrole: Formation and Rearrangement to 2- and 3-Chloropyrrole

N-Chloropyrrole (2) was formed in 65-72percent yield when pyrrole (1) in CCl4 was chlorinated with aqueous NaOCl.This intermediate rearranged in methanol to give chloropyrroles by two distinct reactions: a thermal rearrangement which gave 2-chloropyrrole (3) and an acid-catalyzed intermolecular reaction which gave 2-chloropyrrole (3), 3-chloropyrrole (4), and 2,5-dichloropyrrole (5).Nucleophilic attack on the N-Cl bond of 2 was demonstrated by reactions in the presence of CN- and SCN-.In the latter case, 2-(thiocyano)pyrrole was formed.