17573-83-0Relevant academic research and scientific papers
Trisubstituted pyrimidine derivatives from tetrafluoropyrimidine
Parks, Emma L.,Sandford, Graham,Yufit, Dmitry S.,Howard, Judith A.K.,Christopher, John A.,Miller, David D.
experimental part, p. 6195 - 6204 (2010/09/15)
The use of tetrafluoropyrimidine as a scaffold for the synthesis of 2,4,6-trisubstituted pyrimidine derivatives by three sequential nucleophilic aromatic substitution processes is assessed. Reactions of tetrafluoropyrimidine with various amine nucleophiles followed by a series of nitrogen and oxygen centred nucleophilic species gave a range of 4,6-disubstituted-2,5- difluoropyrimidine systems regioselectively and in good yield. Displacement of a further fluorine atom from representative difluoropyrimidine derivatives proceeded to give trisubstituted pyrimidine derivatives although mixtures of products could be obtained depending upon the substrate.
