767-79-3

Usage

Uses

Used in Organic Synthesis:
2,4,5,6-Tetrafluoropyrimidine is used as a synthetic intermediate for the creation of various organic compounds. Its unique structure and fluorinated nature contribute to the development of new chemical entities with distinct properties, which can be further explored for their applications in different fields.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2,4,5,6-Tetrafluoropyrimidine is employed as a key building block in drug development. Its incorporation into the molecular structures of potential medicinal compounds allows for the enhancement of pharmacokinetic and pharmacodynamic properties, such as solubility, stability, and bioavailability. 2,4,5,6-Tetrafluoropyrimidine's specific attributes make it a valuable asset in the design and synthesis of new drugs with improved therapeutic profiles.
Used in Medicinal Chemistry:
2,4,5,6-Tetrafluoropyrimidine is utilized in medicinal chemistry as a structural component of drug candidates. Its presence in these molecules can modulate their interaction with biological targets, such as enzymes, receptors, or nucleic acids, leading to the discovery of new therapeutic agents with novel mechanisms of action.
The specific properties and potential uses of 2,4,5,6-Tetrafluoropyrimidine in drug development are subjects of ongoing research and investigation, with the aim of uncovering its full potential in the creation of innovative and effective pharmaceuticals.

InChI:InChI=1/C4F4N2/c5-1-2(6)9-4(8)10-3(1)7

Upstream product

• 1780-40-1 2,4,5,6-tetrachloropyrimidine 
• 7627-80-7 tetrafluoropyridazine 
• 696-82-2 2,4,6-trifluoropyrimidine 
• 55827-89-9 perfluoro-4,5-di-s-butylpyridazine 

Downstream Products

• 93832-50-9 2,5,6-trifluoro-4-(2,4,6-trimethylphenylazo)pyrimidine 
• 17573-83-0 2,5,6-trifluoro-N-phenylpyrimidin-4-amine 
• 697-83-6 2,4,6-trifluoro-5-chloropyrimidine 

Relevant academic research and scientific papers

Polyhalogenoheterocyclic Compounds. Part 23. Mechanism of Thermal Rearrangements of Perfluoropyridazine and Perfluoroalkylpyridazines

Rearrangement of perfluoro-4,5-di-s-butylpyridazine (4) to a mixture of perfluoro-4,5-di-s-butylpyrimidine (13) and -2,5-di-s-butylpyrazine (20), occurs at 300 deg C, in a sealed tube.Cross-over experiments between various fluorinated pyridazine derivatives and, also, doubly 15N-labelled derivatives, rule out any rearrangement mechanism involving a cycloaddition process.Compound (4) and other fluorinated compounds act as promoters for the rearrangement of various fluorinated pyridazine derivatives and this process is now most reasonably regarded as a free-radical promoted formation of valence isomers.

Reactions Involving Fluoride Ion. Part 40. Amines as Initiators of Fluoride Ion Catalysed Reactions

Tetrakis(dimethylamino)ethene (TDAE) and trimethylamine react with anhydrous unsaturated fluorocarbons to produce, 'in situ', powerful fluoride-ion sources.These are used to iniate carbon-carbon bond forming reactions eg. oligomerisation and polyfluoroalkylation, and many of these reactions occur efficiently in the absence of a solvent.

Process for the preparation of 5-fluoropyrimidines

5-Fluoropyrimidines are obtained in an advantageous manner from halogenated 5-unsubstituted pyrimidines, when these are reacted with elemental fluorine in the presence of a solvent.

SUBSTITUTIVE AROMATIC FLUORINATION WITH CHLORINE PENTAFLUORIDE

In contrast to limited substitutive fluorination of aromatics with halogen fluorides such as ClF, ClF3, BrF3 and IF5, fluorination is the predominant reaction path with ClF5.Under non-catalytic liquid phase conditions, benzene was converted to fluorobenzene (54percent yield) and chlorobenzene (37percent yield), respectively.For a heterocyclic substrate, i.e. 2,4,6-trifluoropyrimidine, sunstitutive fluorination predominated over chlorination.Three possible fluorination mechanisms are discussed.A transition complex of ClF5 with benzene is favored.Enhanced exchange fluorination of CCl4 was effected with ClF5 (CF2Cl2 >> CFCl3 > CF3Cl) as compared with ClF3 (CFCl3 >> CF2Cl2)

Detection of a Transient after Flash Photolysis of Perfluorinated Diazines in the Gas Phase

Mass spectrometric evidence indicates that flash photolysis of tetrafluoro-pyridazine, -pyrimidine, and -pyrazine produced short-lived isomers with a fulvene-type structure; the values of the rate constants for the formation and decay are given.

LES FLUORATIONS COMPAREES DES CHLOROPYRIMIDINES ET DE LA CHLORO-S-TRIAZINE

The fluorinations of tetrachloropyrimidine, 2,4,6-trichloropyrimidine and trichloro-s-triazine were carried out in sealed tubes with KF in presence of inert gas and then compared.The fluorinated derivatives C4FxClyN2 with x + y = 4, O - were investigated and compared; the molar yields were found to be always higher than 50percent in our experimental conditions.We compare with the fluorinations of 2,4 and 4,6-dichloropyrimidine.It is possible to obtain directlyin good proportions, such fluorinated derivatives as 5-chlorotrifluoropyrimidine, trifluoropyrimidine and others.At high temperature (4OO deg C for 16h), tetrachloropyrimidine, in presence of KF, gave products of pyrolysis and condensation such as the fluorinated derivatives of C6Cl6 and C5Cl5N: C6FCl5, C6F2Cl4... or C5FCl4N, C5F2Cl3N...