175730-16-2

Upstream product

• 79-22-1 methyl chloroformate 
• 175730-15-1 (2R,3S)-N-benzyl-3,4-bis(benzyloxy)butan-2-amine 
• 238401-87-1 (R)-2,3-di-O-benzylglyceraldehyde N-benzylimine 
• 100-46-9 benzylamine 
• 20196-70-7 (+)-(R)-2,3-bis(benzyloxy)propanal 

Relevant academic research and scientific papers

Stereoselective synthesis of α-hydroxy-β-amino acids using D-glyceraldehyde as the homochiral source

A systematic study of the diastereoselective addition of methyl organometallic compounds to the benzyl imine derived from conveniently protected D-glyceraldehyde in order to develop a new approach to enantiomerically pure α-hydroxy-β-amino acids is reported. Methylmagnesium bromide addition afforded the corresponding adduct, which can be further elaborated to give (2S,3R) 3-amino-2-hydroxybutanoic acid, with complete diastereoselectivity.