238401-87-1

Upstream product

• 20196-70-7 (+)-(R)-2,3-bis(benzyloxy)propanal 
• 100-46-9 benzylamine 

Downstream Products

• 175730-15-1 (2R,3S)-N-benzyl-3,4-bis(benzyloxy)butan-2-amine 
• 180324-50-9 (2R,3S)-2-benzylamino-3,4-dibenzyloxybutyronitrile 
• 189516-44-7 (R)-N-benzyl-2-[(S)-1,2-dibenzyloxyethyl]-5,6-dihydro-4-pyridone 
• 649135-94-4 (3R,4S)-3-benzylamino-4,5-bis-benzyloxy-2,2-dimethylpentanoic acid methyl ester 
• 175730-16-2 (2R,3S)-N-benzyl-3,4-dibenzyloxy-N-methoxycarbonyl-2-butylamine 
• 168211-10-7 (1S,2S)-1-benzylamino-2,3-dihydroxybutyric acid 
• 188200-10-4 Benzyl-((1R,2S)-2,3-bis-benzyloxy-1-phenyl-propyl)-carbamic acid tert-butyl ester 
• 649136-02-7 (3R,4S)-4,5-Bis-benzyloxy-3-tert-butoxycarbonylamino-2,2-dimethyl-pentanoic acid methyl ester 
• 188200-09-1 (1R,2S)-N-Benzyl-2,3-dibenzyloxy-1-phenyl-1-propylamine 

Relevant academic research and scientific papers

Asymmetric hetero Diels-Alder reaction of N-benzylimines derived from R-glyceraldehyde: A new approach to homochiral piperidine building blocks and its application to the synthesis of (2R)-4-oxopipecolic acid

The N-Benzyl imine derived from 2,3-di-O-benzyl-D-glyceraldehyde reacts with Danishefsky's diene to afford the corresponding hetero Diels-Alder adduct with a high diastereoselectivity. This compound can be transformed to enantiomerically pure (2R)-4-oxopi

Stereoselective synthesis of α-hydroxy-β-amino acids using D-glyceraldehyde as the homochiral source

A systematic study of the diastereoselective addition of methyl organometallic compounds to the benzyl imine derived from conveniently protected D-glyceraldehyde in order to develop a new approach to enantiomerically pure α-hydroxy-β-amino acids is reported. Methylmagnesium bromide addition afforded the corresponding adduct, which can be further elaborated to give (2S,3R) 3-amino-2-hydroxybutanoic acid, with complete diastereoselectivity.

Diastereoselective strecker reaction of D-glyceraldehyde derivatives. A novel route to (2S,3S)- and (2R,3S)-2-amino-3,4-dihydroxybutyric acid

Efficient and stereoselective synthetic routes to enantiomerically pure (2S,3S)- and (2S,3S)-2-amino-3,4-dihydroxybutyric acid have been developed using the stereoselective Strecker type reaction of carbonyl compounds derived from appropriately protected