17575-27-8Relevant academic research and scientific papers
Iodocyclization versus diiodination in the reaction of 3-alkynyl-4- methoxycoumarins with iodine: Synthesis of 3-iodofuro[2,3-b]chromones
Raffa, Guillaume,Belot, Sebastien,Balme, Genevieve,Monteiro, Nuno
supporting information; experimental part, p. 1474 - 1478 (2011/04/15)
The reaction of 3-alkynyl-4-methoxycoumarins with molecular iodine in chlorinated solvents allows access to 3-iodofurochromones in good to excellent yields as the result of a iodocyclization-demethylation process. Competitive diiodination of the coumarin acetylene moiety could be eliminated by simply performing the reactions in refluxing 1,2-dichloroethane, owing to the thermal instability of the resulting (E)-1,2-diiodoethenylcoumarins. The Royal Society of Chemistry 2011.
Hydroxycoumarin derivatives: Novel and potent α-glucosidase inhibitors
Shen, Qiong,Shao, Jialiang,Peng, Quan,Zhang, Wanjin,Ma, Lin,Chan, Albert S. C.,Gu, Lianquan
experimental part, p. 8252 - 8259 (2011/02/23)
A novel class of hydroxycoumarin derivatives were found to be potent α-glucosidase inhibitors. Their syntheses were reported and the structure-activity relationship was established. Kinetic enzymatic assays indicated that compound 10 was a slow-binding and noncompetitive inhibitor with a Ki value of 589 nM, while compound 11 was a competitive inhibitor with a Ki value of 4.810 μM. Among all hydroxycoumarin derivatives studied, compounds 10 and 11 exhibited the highest activities, were specific inhibitors of α-glucosidase, and could be exploited as the lead compounds for the development of potent α-glucosidase inhibitors. Compounds 10 and 11 were also selected for further discussion for the mechanism of enzymatic inhibition.
