22089-12-9

Usage

Uses

Used in Skincare Industry:
Ethanone, 1-(2,5-dihydroxy-4-methoxyphenyl)is used as a skin-lightening agent for its ability to inhibit the enzyme tyrosinase, reducing melanin production and helping to lighten dark spots and improve overall skin tone.
Ethanone, 1-(2,5-dihydroxy-4-methoxyphenyl)is also used as an antioxidant in skincare products due to its ability to neutralize free radicals, protecting the skin from oxidative stress and damage.
Additionally, arbutin is used as an anti-inflammatory agent in skincare formulations, helping to reduce inflammation and redness associated with various skin conditions.

Upstream product

• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 20628-06-2 2-hydroxy-4,5-dimethoxyacetophenone 
• 69470-86-6 1-(5-acetoxy-2-hydroxy-4-methoxy-phenyl)-ethanone 
• 75514-03-3 2-methoxy-p-hydroquinone diacetate 
• 93483-92-2 1-(5-amino-2-hydroxy-4-methoxyphenyl)ethanone 
• 824-46-4 methoxyhydroquinone 
• 1818-27-5 1-(2,4,5-trihydroxyphenyl)ethanone 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 108-24-7 acetic anhydride 
• 74-88-4 methyl iodide 
• 64-19-7 acetic acid 
• 829-20-9 2',4'-dimethoxyacetophenone 
• 102877-53-2 1-(2-hydroxy-4-methoxy-5-nitrophenyl)ethanone 
• 17575-27-8 4,7-dimethoxyy-2H-chromen-2-one 

Downstream Products

• 52249-88-4 1-(5-(benzyloxy)-2-hydroxy-4-methoxyphenyl)ethan-1-one 
• 105253-88-1 1-(5-allyloxy-2-hydroxy-4-methoxy-phenyl)-ethanone 
• 2015-81-8 4-Methoxy-2,5-dibenzyloxy-acetophenon 
• 13618-45-6 methyl 2,5-dihydroxy-4-methoxybenzoate 
• 42189-58-2 2-Hydroxy-4-methoxy-5-methoxymethoxy-benzoic acid 
• 5981-37-3 2,5-dihydroxy-4-methoxybenzoic acid 
• 102171-96-0 1-(2-allyl-6-benzyloxy-3-hydroxy-4-methoxy-phenyl)-ethanone 
• 102019-01-2 1-(5-allyloxy-2-benzoyloxy-4-methoxy-phenyl)-ethanone 
• 102171-97-1 1-(5-allyloxy-2-benzyloxy-4-methoxy-phenyl)-ethanone 
• 263138-69-8 2-allyl-3,4,6-trimethoxyacetophenone 
• 100612-87-1 1-(2-allyl-3-hydroxy-4,6-dimethoxyphenyl)ethanone 

Relevant academic research and scientific papers

Discovery of O6-benzyl glaziovianin A, a potent cytotoxic substance and a potent inhibitor of α,β-tubulin polymerization

We have discovered O6-benzyl glaziovianin A, which showed stronger inhibition of microtubule polymerization (IC50?=?2.1?μM) than known α,β-tubulin inhibitors, such as colchicine and glaziovianin A. Also, we performed competition binding experiments of O6-benzyl glaziovianin A and revealed that O6-benzyl glaziovianin A binds to the colchicine binding site with high affinity. It is interesting that glaziovianin A derivatives change their mode of action in benzylation at the O6(α,β-tubulin inhibitor) or O7(γ-tubulin-specific inhibitor) position.

Iron-catalyzed arene C-H hydroxylation

The sustainable, undirected, and selective catalytic hydroxylation of arenes remains an ongoing research challenge because of the relative inertness of aryl carbon-hydrogen bonds, the higher reactivity of the phenolic products leading to over-oxidized by-products, and the frequently insufficient regioselectivity. We report that iron coordinated by a bioinspired L-cystine-derived ligand can catalyze undirected arene carbon-hydrogen hydroxylation with hydrogen peroxide as the terminal oxidant. The reaction is distinguished by its broad substrate scope, excellent selectivity, and good yields, and it showcases compatibility with oxidation-sensitive functional groups, such as alcohols, polyphenols, aldehydes, and even a boronic acid. This method is well suited for the synthesis of polyphenols through multiple carbon-hydrogen hydroxylations, as well as the late-stage functionalization of natural products and drug molecules.

Method For Producing Low Molecular Weight Aromatic Lignin-Derived Compounds

The present invention relates to a method for producing one or more low molecular weight aromatic lignin-derived compounds. The method preferably comprises providing lignocellulosic material, subjecting the lignocellulosic material to a pulping process, separating pulp to provide a substantially pulp-free process stream comprising a modified lignin-derived component, isolating the modified lignin-derived component, subjecting the isolated modified lignin-derived component to a decomposition step comprising oxidative cracking (cracking and oxidizing) or reducing under the influence of a catalyst or electro-oxidation, and subjecting the resulting products to an isolation step, to provide a low molecular weight aromatic lignin-derived compound. Said compound may be further modified, e.g. by annulation. The inventive method preferably comprises further oxidizing said compound to a redox active compound. Additionally, the present invention relates to compounds obtainable by the inventive method and to an assembly for carrying out the inventive method. Furthermore, the present invention refers to a method for providing an existing pulp and/or paper manufacturing plant with said assembly.

AMINATED LIGNIN-DERIVED COMPOUNDS AND USES THEREOF

The present invention relates to novel lignin-derived compounds and compositions comprising the same and their use as redox flow battery electrolytes. The invention further provides a method for preparing said compounds and compositions as well as a redox flow battery comprising said compounds and compositions. Additionally, an assembly for carrying out the inventive method is provided.

Micro tube polymn. inhibitor (by machine translation)

PROBLEM TO BE SOLVED: micro tube polymn. inhibitory activity, as of cytokinetic promisingness. SOLUTION: compd. eq. (I) or pharmaceutically acceptable salt thereof is represented. (A cycloalkyl group, an aryl group, an alkyl or heterocyclyl group; R1, an alkenyl group, an alkynyl group or aryl alkyl group; m is an integer) selected drawing 1-8:no (by machine translation)

Divergent Total Syntheses of Flavonoid Natural Products Isolated from Rosa rugosa and Citrus unshiu

The concise and step-economical total syntheses of three hydroxyaurones and one polymethoxyflavone from readily available starting materials is described. A divergent synthetic strategy is employed, which centres on a common chalcone scaffold from which both the aurone and flavone frameworks can be accessed through the use of different oxidative cyclisation methods. These are the first reported total syntheses of these biologically interesting compounds.

Inhibitors for expression of IgE receptor on human mast cell from Puerariae Flos

Bioassay-guided separation of the extract of the medicinal plant, Puerariae Flos, disclosed the two isoflavones tectorigenin (1) and genistein (2) as the inhibitors for expression of IgE receptor (FcRI), the key molecule triggering the allergic reactions, on human mast cells. As a result of analysis of structure-activity relationship of the naturally occurring and synthesized isoflavones, 7-O-methyl glycitein (11) was disclosed as the more potent inhibitor than tectorigenin (1). These isoflavone ingredients suppressed expression of FcRI more potently than the active flavonoids found previously. In addition, tectorigenin (1) was clarified to particularly reduce generation of γ-chain subunit to suppress expression of FcRI among the three subunits.

Studies on the metabolism of propafenone. 1st comm.: Synthesis and chromatographic/mass spectrometric properties of the labelled compound and of the reference substances

The synthesis of 14C-propafenone and 2H-propafenone (propafenone: 2-(2'-hydroxy-3'-propylamino-propoxy)-ω-phenyl-propiophenone hydrochloride) and some reference compounds is described. The thin-layer chromatographic, high-performance liquid and gas chromatographic properties of the substances are described. Propafenone and the reference substances were studied by mass spectrometry and compared with each other, with respect to structural elucidation of the metabolites. The chromatographic and mass spectrometric data (key ions) enables the metabolites of propafenone to be identified in biological material.