17576-35-1

Basic information

• Product Name: 1,3,3-TRIMETHOXYPROPENE
• Synonyms: 1,3,3-TRIMETHOXYPROPENE;(1E)-1,3,3-Trimethoxy-1-propene;1,3,3-Trimethoxy-1-propene;1-Propene, 1,3,3-trimethoxy-;Acrolein, 3-methoxy-, dimethyl acetal;3-Methoxyacrylaldehyde dimethyl acetal;1,3,3-Trimethoxypropene,96%,pract.
• CAS NO: 17576-35-1
• Molecular Formula: C₆H₁₂O₃
• Molecular Weight: 132.16
• EINECS: 241-547-7
• Mol File: 17576-35-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 97.3°Cat760mmHg
• Flash Point: 27°C
• Appearance: /
• Density: 0.939g/cm³
• Vapor Pressure: 48mmHg at 25°C
• Refractive Index: 1.413
• CAS DataBase Reference: 1,3,3-TRIMETHOXYPROPENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,3-TRIMETHOXYPROPENE(17576-35-1)
• EPA Substance Registry System: 1,3,3-TRIMETHOXYPROPENE(17576-35-1)

Safety Data

• RIDADR: 1993
• HazardClass: 3.2
• PackingGroup: III
• Hazardous Substances Data: 17576-35-1(Hazardous Substances Data)

Usage

General Description

1,3,3-Trimethoxypropene is a chemical compound primarily used in organic synthesis. This substance with a formula of C6H12O3 belongs to the organic class of compounds called acetals which are made up of two distinct alkoxy (OR) groups directly attached to the same carbon atom. It is slightly soluble in water, readily soluble in organic solvents, and has a heavy, fruity, and floral taste or smell. As part of its safety precautions, it is not classified as a dangerous or hazardous substance and considered low in toxicity. However, it may cause eye, skin and respiratory tract irritation on direct contact or inhalation.

InChI:InChI=1/C6H12O3/c1-7-5-4-6(8-2)9-3/h4-6H,1-3H3

Upstream product

• 759-97-7 2-bromo-1,1,3-trimethoxy-propane 
• 759-98-8 2-chloro-1,1,3-trimethoxy-propane 

Downstream Products

• 92199-88-7 2-benzylsulfanyl-4-(3-methoxy-allylidene)-4H-thiazol-5-one 
• 28633-58-1 1,3-bis-(2,3-diphenyl-indolizin-1-yl)-trimethinium ; bromide 
• 36536-22-8 1,3,3,1',3',3'-hexamethylindodicarbocyanide iodide 
• 83710-89-8 C₃₉H₂₉Te₂⁽¹⁺⁾*BF₄^(1-) 
• 100727-47-7 4-(3-methoxy-allylidene)-2-phenyl-4H-oxazol-5-one 

Relevant articles and documents

Claisen Orthoester Rearrangement in the Direct Preparation of Z-Isositsirikine and Z-Geissoschizine Derivatives Possessing the Right Oxidation State at C-17

The Claisen orthoester rearrangement utilizing allylic alcohol 1 (or 2) and trimethyl 3-methoxyorthopropionate 13a leads to Z-isositsirikine derivatives 21a-22a (or 23a-24a) possessing one RO-function at C-17.In the cases of trialkyl 3,3-dialkoxyorthopropionates , the intermediate ketene acetals 25a,b do not rearrange according to the Claisen mechanism to form compounds 26a,b and/or possessing two two RO-functions at C-17.Syntheses of the intermediate orthoesters, trimethyl 3-methoxyorthopropionate 13a, trimethyl 3,3-dimethoxyorthopropionate 14a, trimethyl trans-3-methoxyorthoacrylate 20c, and triethyl 3,3-diethoxyorthopropionate 14b are described.