175782-96-4Relevant academic research and scientific papers
Heterocyclic derivatives of azolones
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, (2008/06/13)
The invention is concerned with the compounds having the formula STR1 the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Y is CH or N; R1, R2 and R3 each independently are hydrogen or C1-4 alkyl; R4 and R5 each independently are hydrogen, halo, C1-4 alkyl, C1-4 alkyloxy, hydroxy, trifluoromethyl, trifluoromethyloxy or difluoromethyloxy; R6 is pyridinyl optionally substituted with up to two C1-4 alkyl groups; di(C1-4 alkyl) hydroxypyridinyl; di(C1-4 alkyl)C1-4 alkyloxypyridinyl; pyridazinyl optionally substituted with C1-4 alkyloxy; pyrimidinyl optionally substituted with hydroxy or C1-4 alkyloxy; thiazolyl optionally substituted with C1-4 alkyl; thiadiazolyl optionally substituted with C1-4 alkyl; benzoxazolyl or benzothiazolyl; or R6 is pyrazinyl or pyridazinyl substituted with C1-4 alkyl; Z is C=O or CHOH; and STR2 is a radical of formula STR3 Compositions comprising said compounds, processes for preparing the same and the use of these compounds as a medicine.
