175857-65-5Relevant academic research and scientific papers
A new synthetic route to 2-alkyl-4-aryl-1(2H)-isoquinolones and 2-alkyl-4-aryl-1,2,3,4-tetrahydroisoquinolines
Couture, Axel,Deniau, Eric,Grandclaudon, Pierre,Woisel, Patrice
, p. 4433 - 4448 (1996)
4-Aryl and heteroaryl-1(2H)-isoquinolones have been prepared by base promoted cyclization of phosphorylated o-aroyl and heteroaroyl benzamides. Subsequent reduction of the carbonyl and styryl functions of the annulated products has given rise to 4-aryl-1,2,3,4-tetrahydroisoquinolines.
Synthesis of bicyclic carbamates as precursors of Sedum alkaloid derivatives
Szakonyi, Zsolt,D'Hooghe, Matthias,Kanizsai, Iván,Fül?p, Ferenc,De Kimpe, Norbert
, p. 1595 - 1602 (2007/10/03)
Synthesis of a N-Boc-protected piperidin-2-yl phosphine oxide starting from piperidine in three steps, followed by olefination using a variety of α,β-unsaturated aldehydes resulted in tert-butyl 2-(2′- alkenylidene)piperidine-1-carboxylates in high yields
First synthesis and pharmacological evaluation of benzoindolizidine and benzoquinolizidine analogues of α- and β-peltatin
Couture, Axel,Deniau, Eric,Grandclaudon, Pierre,Lebrun, Stephane,Leonce, Stephane,Renard, Pierre,Pfeiffer, Bruno
, p. 2113 - 2125 (2007/10/03)
The benzoindolizidine and-quinolizidine analogues of α- and β-peltatin were designed and synthesized by two different synthetic routes involving as the key step the Bischler-Napieralski cyclization of suitably substituted N-acyl-2-arylmethylpyrrolidine and -piperidine derivatives. The in vitro biological activity of these analogues as well as some of their derivatives was subsequently evaluated. Copyright (C) 2000 Elsevier Science Ltd.
An efficient synthesis of 5-(or 6-)-arylbenzoindolizidine and - quinolizidine derivatives
Lebrun, Stephane,Couture, Axel,Deniau, Eric,Grandclaudon, Pierre
, p. 2345 - 2352 (2007/10/03)
A new methodology for the synthesis of (hetero)arylated benzomdolizidine and benzoquinolizidine derivatives through sequential reduction of pyrrolidine- and piperidine-based aromatic enamides, and ultimate cyclization, is reported.
Dramatically different photochemical behaviour of 1-aroyl-2-methylene piperidine and pyrrolidine derivatives. An expeditious synthesis of ruspolinone
Couture,Deniau,Grandclaudon,Lebrun
, p. 7749 - 7752 (2007/10/03)
Upon irradiation in neutral solvent, the diversely substituted 1-aroyl-2-methylenepiperidines 6a-f give rise to photocyclized products 4a-f while their pyrrolidine congeners 7a,c,d afford enaminoketones 18a,c,d products of photo-Fries rearrangement.
