223477-90-5Relevant academic research and scientific papers
Synthesis of bicyclic carbamates as precursors of Sedum alkaloid derivatives
Szakonyi, Zsolt,D'Hooghe, Matthias,Kanizsai, Iván,Fül?p, Ferenc,De Kimpe, Norbert
, p. 1595 - 1602 (2007/10/03)
Synthesis of a N-Boc-protected piperidin-2-yl phosphine oxide starting from piperidine in three steps, followed by olefination using a variety of α,β-unsaturated aldehydes resulted in tert-butyl 2-(2′- alkenylidene)piperidine-1-carboxylates in high yields
First synthesis and pharmacological evaluation of benzoindolizidine and benzoquinolizidine analogues of α- and β-peltatin
Couture, Axel,Deniau, Eric,Grandclaudon, Pierre,Lebrun, Stephane,Leonce, Stephane,Renard, Pierre,Pfeiffer, Bruno
, p. 2113 - 2125 (2007/10/03)
The benzoindolizidine and-quinolizidine analogues of α- and β-peltatin were designed and synthesized by two different synthetic routes involving as the key step the Bischler-Napieralski cyclization of suitably substituted N-acyl-2-arylmethylpyrrolidine and -piperidine derivatives. The in vitro biological activity of these analogues as well as some of their derivatives was subsequently evaluated. Copyright (C) 2000 Elsevier Science Ltd.
Total syntheses of (±)-cryptopleurine, (±)-antofine and (±)- deoxypergularinine
Lebrun, Stephane,Couture, Axel,Deniau, Eric,Grandclaudon, Pierre
, p. 2659 - 2670 (2007/10/03)
The alkaloids (±)-cryptopleurine 1, (±)-antofine 2, and (±)- deoxypergularinine 3 were synthesized by Pictet-Spengler cyclization of the 2-arylmethylpiperidine and -pyrrolidines 4, 5 and 6 obtained by sequential N- deprotection-reduction of the parent ene
