17590-38-4Relevant academic research and scientific papers
Methyl sydnone imine and its energetic salts
Gettings, Matthew L.,Byrd, Edward F. C.,Zeller, Matthias,Piercey, Davin
, p. 2228 - 2236 (2021)
Several energetic salts of the 5-amino-3-methyl-1,2,3-oxadiazolium cation were synthesized and characterized. Structures are confirmed by IR,1H and13C NMR spectroscopy, and X-ray crystallography. The perchlorate salt was thermally stable, with a crystal density of 1.826 g cm?3and its calculated energetic performance exceeded that of TNT. Except for the perchlorate, these salts are mechanically insensitive. This work explored the methyl sydnone imine cation as a suitable energetic compound, which was quickly obtained through facile syntheses. This is the first exploration of sydnone imines as components of energetic materials.
New NO-donors with antithrombotic activities and vasodilating activities, III: 3,4-disubstituted N-nitroso-5-sydnone imines
Rehse,Schleifer
, p. 929 - 939 (2007/10/02)
38 title compounds have been synthesized. They bear a wide variety in substituents including alkyl-, aryl-, arylalkyl-, and styryl groups. The antiplatelet activities elucidated in the Born-test with collagen cover more than two orders of magnitude (IC50 = 0.3-45 μmol/L). These effects depend on the presence of the N-NO-group. This is shown by comparison with the corresponding sydnone imines, sydnone cyanimines, and sydnones. The most suitable substituents were phenylethyl, styryl, and hexyl at either position of the molecule. Seven compounds, most of them styryl derivatives, have IC50 values below 1 μmol/L. It is suggested that the differences in activity are connected with the ability of the compounds to bind to the platelet membrane.
