175965-82-9

Basic information

• Product Name: 4-Ethoxy-2-Fluoropyridine
• Synonyms: 4-Ethoxy-2-Fluoropyridine;Pyridine, 4-ethoxy-2-fluoro- (9CI)
• CAS NO: 175965-82-9
• Molecular Formula: C7H8FNO
• Molecular Weight: 141.1429232
• Product Categories: PYRIDINE
• Mol File: 175965-82-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 187.1 °C at 760 mmHg
• Flash Point: 67 °C
• Appearance: /
• Density: 1.108g/cm³
• Vapor Pressure: 0.88mmHg at 25°C
• Refractive Index: 1.471
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.87±0.10(Predicted)
• CAS DataBase Reference: 4-Ethoxy-2-Fluoropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Ethoxy-2-Fluoropyridine(175965-82-9)
• EPA Substance Registry System: 4-Ethoxy-2-Fluoropyridine(175965-82-9)

Safety Data

• Hazardous Substances Data: 175965-82-9(Hazardous Substances Data)

Usage

General Description

4-Ethoxy-2-Fluoropyridine is a chemical compound with the molecular formula C7H7NO. It is a clear, colorless liquid with a strong, sweet odor. It is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals. 4-Ethoxy-2-Fluoropyridine is known for its low volatility, high thermal stability, and excellent solubility in various organic solvents. It is also used as a building block in the production of pyridine-based compounds, which are widely used in the pharmaceutical and agricultural industries. Additionally, 4-Ethoxy-2-Fluoropyridine is considered to be of low toxicity and does not pose significant health or environmental risks when handled and used properly.

InChI:InChI=1/C7H8FNO/c1-2-10-6-3-4-9-7(8)5-6/h3-5H,2H2,1H3

Upstream product

• 34941-90-7 2,4-difluoropyridine 
• 141-52-6 sodium ethanolate 
• 175965-86-3 3,5-dichloro-4-ethoxy-2-fluoropyridine 

Relevant articles and documents

Ortho-selectivity in SNAr substitutions of 2,4-dihaloaromatic compounds. Reactions with anionic nucleophiles

The nucleophilic addition of organic anions to aromatic compounds with halogens positioned both ortho and para to activating groups was studied in a variety of solvents. Substrates showed strong preferences for ortho substitution in most cases. Evidence is presented for activating group-dependent coordination, which contributes to very high ortho-selectivity in nonpolar solvents. This also drives the overall reaction rate in these solvents, and is of close to the same magnitude of rate increase derived from polar solvents. para-Products are maximized by using crown ethers in protic solvents. Solvent effects overall are very different from corresponding reactions with amine nucleophiles due primarily to the different charges present in the transition states, and to solvation of the nucleophile.

N-aryl[1,2,4]triazolo[1,5-a]pyridine-2-sulfonamide herbicides

Substituted N-aryl[1,2,4]triazolo[1,5-a]pyridine-2-sulfonamide compounds, such as N-(2,6-difluorophenyl)-5-methoxy-7-methyl[1,2,4]triazolo[1,5-a]pyridine-2-sulfonamide, N-(4-bromo-1-methyl-3-pyrazoly)-8-chloro-5-methoxy[1,2,4]triazolo[1,5-a]pyridine-2-sulfonamide, and N-(2-fluoro-4-methyl-3-pyridinyl)-8-ethoxy-6-chloro[1,2,4]triazolo[1,5-a]-pyridine-2-sulfonamide, were prepared by condensation of a 2-chlorosulfonyl[1,2,4]triazolo[1,5-a]pyridine compound with an aryl amine. The compounds prepared were found to possess excellent herbicidal activity on a broad spectrum of vegetation at low application rates.