175965-82-9

Usage

Uses

Used in Pharmaceutical Industry:
4-Ethoxy-2-Fluoropyridine is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of pyridine-based compounds. These compounds are integral in the creation of various medications, enhancing the therapeutic potential of new drugs.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Ethoxy-2-Fluoropyridine is utilized as a building block in the production of agrochemicals. Its role in formulating effective and stable pesticides and other agricultural chemicals is vital for improving crop protection and yield.
Used as a Specialty Chemicals Intermediate:
4-Ethoxy-2-Fluoropyridine also serves as an intermediate for the synthesis of specialty chemicals outside of the pharmaceutical and agrochemical realms. Its unique properties make it suitable for a variety of applications, including the development of new materials and chemical processes.
Given its low toxicity and minimal health or environmental risks when handled properly, 4-Ethoxy-2-Fluoropyridine is a preferred choice for many chemical synthesis processes where safety and stability are paramount.

InChI:InChI=1/C7H8FNO/c1-2-10-6-3-4-9-7(8)5-6/h3-5H,2H2,1H3

Upstream product

• 34941-90-7 2,4-difluoropyridine 
• 141-52-6 sodium ethanolate 
• 175965-86-3 3,5-dichloro-4-ethoxy-2-fluoropyridine 

Relevant academic research and scientific papers

Ortho-selectivity in SNAr substitutions of 2,4-dihaloaromatic compounds. Reactions with anionic nucleophiles

The nucleophilic addition of organic anions to aromatic compounds with halogens positioned both ortho and para to activating groups was studied in a variety of solvents. Substrates showed strong preferences for ortho substitution in most cases. Evidence is presented for activating group-dependent coordination, which contributes to very high ortho-selectivity in nonpolar solvents. This also drives the overall reaction rate in these solvents, and is of close to the same magnitude of rate increase derived from polar solvents. para-Products are maximized by using crown ethers in protic solvents. Solvent effects overall are very different from corresponding reactions with amine nucleophiles due primarily to the different charges present in the transition states, and to solvation of the nucleophile.

N-pyridinyl[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonamide herbicides

Substituted N-pyridinyl[1,2,4]triazolo[1,5-c]-pyrimidine-2-sulfonamide compounds, such as N-(2-fluoro-4-methyl)-7-fluoro-5-methoxy[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonamide, were prepared bycondensation of a 2-chlorosulfonyl[1,2,4]triazolo[1,5-c]pyrimidine compound, such as 2-chlorosulfonyl-7-fluoro-5-methoxy[1,2,4]triazolo[1,5-c]pyrimidine, with a substituted 3-aminopyridine compound, such as 3-amino-2-fluoro-4-methylpyridine, and found to possess herbicidal utility.

N-aryl[1,2,4]triazolo[1,5-a]pyridine-2-sulfonamide herbicides

Substituted N-aryl[1,2,4]triazolo[1,5-a]pyridine-2-sulfonamide compounds, such as N-(2,6-difluorophenyl)-5-methoxy-7-methyl[1,2,4]triazolo[1,5-a]pyridine-2-sulfonamide, N-(4-bromo-1-methyl-3-pyrazoly)-8-chloro-5-methoxy[1,2,4]triazolo[1,5-a]pyridine-2-sulfonamide, and N-(2-fluoro-4-methyl-3-pyridinyl)-8-ethoxy-6-chloro[1,2,4]triazolo[1,5-a]-pyridine-2-sulfonamide, were prepared by condensation of a 2-chlorosulfonyl[1,2,4]triazolo[1,5-a]pyridine compound with an aryl amine. The compounds prepared were found to possess excellent herbicidal activity on a broad spectrum of vegetation at low application rates.