17598-03-7

Usage

Class

methoxyphenols

Appearance

colorless to pale yellow liquid

Odor

sweet, floral

Uses

flavoring agent in food industry, fragrance ingredient in perfumery industry

Potential applications

organic synthesis, material science

Medicinal properties

anticancer, anti-inflammatory activities

InChI:InChI=1/C11H14O3/c1-5-8-6-10(13-3)11(14-4)7-9(8)12-2/h5-7H,1H2,2-4H3

Upstream product

• 4460-86-0 asaraldehyde 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 1818-28-6 2',4',5'-trimethoxyacetophenone 
• 135-77-3 1,2,4-trimethoxy-benzene 
• 41317-93-5 2,4,5-trimethoxy-α-methylbenzenemethanol 

Downstream Products

• 1306770-73-9 C₂₂H₂₈O₆ 
• 1646623-55-3 2-(methylsulfonyl)-1-(2,4,5-trimethoxyphenyl)ethanone 
• 4460-86-0 asaraldehyde 

Relevant academic research and scientific papers

COMPOUNDS AND THE USE THEREOF IN METATHESIS REACTIONS

The disclosure provides Group 6 complexes, which, in some embodiments, are useful for catalyzing olefin metathesis reactions. In some embodiments, the compounds are compounds of the following formula (I) wherein: M is a Group 6 metal atom; X is an oxygen

An effective system to synthesize hypolipidemic active α-asarone and related methoxylated (E)-arylalkenes

Methoxylated (E)-arylalkenes (1a-1k) were prepared in two steps by an improved Grignard reaction comprising the reverse addition of alkylmagnesium bromide to benzaldehydes (2a-2k) in anhydrous ether and toluene into arylalkanols (3a-3k) in high yield, followed by dehydration with silica gel under microwave irradiation for 3-12 min, depending upon the substituents attached to the aromatic ring to afford hypolipidemic active α-asarone (1a) and related methoxylated (E)-arylalkenes (1b-1k).

Synthesis and hypolipidemic activity of modified side chain α-asarone homologues

A series of homologues of α-asarone (1), containing variable size and functionality on the side chain attached to the aromatic ring, has been subjected to a study of structure-activity relationship. For most of the prepared derivatives, either with a carbonyl (8a-8e), a hydroxy group (9a-9e), or with a conjugated double bond (10a-10d), significant effects on serum lipoprotein cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides were displayed. The results showed an enhancement of the hypocholesterolemic activity as the length of the chain is decreased. Theoretical conformational and electrostatic potential analyses of 1 and olefins 10 suggest unfavorable steric interactions in the bulky superior side-chain homologues as the deactivating biological effect.