17598-03-7Relevant articles and documents
COMPOUNDS AND THE USE THEREOF IN METATHESIS REACTIONS
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Page/Page column 50, (2015/11/18)
The disclosure provides Group 6 complexes, which, in some embodiments, are useful for catalyzing olefin metathesis reactions. In some embodiments, the compounds are compounds of the following formula (I) wherein: M is a Group 6 metal atom; X is an oxygen
Synthesis and hypolipidemic activity of modified side chain α-asarone homologues
Cruz,Garduno,Salazar,Martinez,Jimenez-Vazquez,Diaz,Chamorro,Tamariz
, p. 535 - 544 (2007/10/03)
A series of homologues of α-asarone (1), containing variable size and functionality on the side chain attached to the aromatic ring, has been subjected to a study of structure-activity relationship. For most of the prepared derivatives, either with a carbonyl (8a-8e), a hydroxy group (9a-9e), or with a conjugated double bond (10a-10d), significant effects on serum lipoprotein cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides were displayed. The results showed an enhancement of the hypocholesterolemic activity as the length of the chain is decreased. Theoretical conformational and electrostatic potential analyses of 1 and olefins 10 suggest unfavorable steric interactions in the bulky superior side-chain homologues as the deactivating biological effect.