17598-10-6

Basic information

• Product Name: 1-Morpholino-1-hexanone
• Synonyms: 1-Morpholino-1-hexanone;4-Hexanoylmorpholine;AI3-35668-aGb
• CAS NO: 17598-10-6
• Molecular Formula: C₁₀H₁₉NO₂
• Molecular Weight: 185.2634
• Mol File: 17598-10-6.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 313.2°Cat760mmHg
• Flash Point: 143.2°C
• Appearance: /
• Density: 0.996g/cm³
• Vapor Pressure: 0.000505mmHg at 25°C
• Refractive Index: 1.464
• PKA: -0.66±0.20(Predicted)
• CAS DataBase Reference: 1-Morpholino-1-hexanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Morpholino-1-hexanone(17598-10-6)
• EPA Substance Registry System: 1-Morpholino-1-hexanone(17598-10-6)

Safety Data

• Hazardous Substances Data: 17598-10-6(Hazardous Substances Data)

Usage

Structure

A ketone derivative containing a morpholine ring

Common uses

Reagent in organic synthesis for the preparation of various compounds

Pharmaceutical and therapeutic applications

Building block in the synthesis of bioactive molecules and pharmaceutical intermediates

Potential use

Development of new materials and in medicinal chemistry research

Industrial and scientific purposes

Unique structure and diverse applications hold promise

InChI:InChI=1/C10H19NO2/c1-2-3-4-5-10(12)11-6-8-13-9-7-11/h2-9H2,1H3

Upstream product

• 110-91-8 morpholine 
• 142-61-0 Hexanoyl chloride 
• 142-62-1 hexanoic acid 
• 111-27-3 hexan-1-ol 
• 134413-96-0 6-bromo-1-(morpholin-4-yl)-hexan-1-one 
• 2767-91-1 4-morpholinopyridine 
• 66-25-1 hexanal 
• 123-66-0 Ethyl hexanoate 
• 628-02-4 Caproamide 
• 6378-65-0 n-hexyl caproate 

Downstream Products

• 110-91-8 morpholine 
• 111-27-3 hexan-1-ol 
• 184877-64-3 (+)-madindoline A 
• 106-68-3 3-octanone 
• 66-25-1 hexanal 

Relevant articles and documents

Defunctionalization of sp3 C–Heteroatom and sp3 C–C Bonds Enabled by Photoexcited Triplet Ketone Catalysts

A general strategy for enabling a light-induced defunctionalization of sp3 C–heteroatom and sp3 C–C bonds with triplet ketone catalysts and bipyridine additives is disclosed. This protocol is characterized by its broad scope without recourse to transition metal catalysts or stoichiometric exogeneous reductants, thus offering a complementary technique for activating σ sp3 C–C(heteroatom) bonds. Preliminary mechanistic studies suggest that the presence of 2,2′-bipyridines improves the lifetime of ketyl radical intermediates.

Iridium-PPh3 Catalysts for Conversion of Amides to Enamines

Studies on the deactivation mechanism of the reaction of N,N-dialkylamides with TMDS catalyzed by Vaska's complex, IrCl(CO)(PPh3)2 (1a), triggered the discovery of highly active Ir-PPh3 catalysts: Photochemically activated

CuCl/TBHP catalyzed synthesis of amides from aldehydes and amines in water

A CuCl/TBHP catalyzed amidation of aldehydes with amine under aqueous media is described. Both aliphatic and aromatic aldehydes coupled with a variety of amines under the reaction conditions employed.