176-33-0

Basic information

• Product Name: 1,4-DIOXA-7-AZA-SPIRO[4.4]NONANE
• Synonyms: 1,4-DIOXA-7-AZA-SPIRO[4.4]NONANE;1,4-Dioxa-4-azaspiro[4.4]nonane;1,4-dioxa-7-azaspiro[4.4]nonane(SALTDATA: FREE);1,4-dioxa-6-azaspiro[4.4]nonane
• CAS NO: 176-33-0
• Molecular Formula: C₆H₁₁NO₂
• Molecular Weight: 129.15704
• Mol File: 176-33-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 206.714 °C at 760 mmHg
• Flash Point: 72 °C
• Appearance: /
• Density: 1.161 g/cm³
• Vapor Pressure: 0.221mmHg at 25°C
• Refractive Index: 1.501
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 1,4-DIOXA-7-AZA-SPIRO[4.4]NONANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-DIOXA-7-AZA-SPIRO[4.4]NONANE(176-33-0)
• EPA Substance Registry System: 1,4-DIOXA-7-AZA-SPIRO[4.4]NONANE(176-33-0)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 39
• HazardClass: IRRITANT
• Hazardous Substances Data: 176-33-0(Hazardous Substances Data)

Usage

General Description

1,4-DIOXA-7-AZA-SPIRO[4.4]NONANE is a chemical compound categorized as a heterocyclic compound with the molecular formula C7H12N2O2. This implies that its structure comprises a ring of atoms that are not all carbon, and includes at least one nitrogen atom and two oxygen atoms. Specific properties such as physical characteristics, boiling point, melting point, etc., rely largely on the conditions in which it is studied or synthesized. It traditionally appears in scientific research contexts especially in the field of synthetic chemistry. More detailed information about it, such as its risk and safety instructions, uses, and potential effects on health and the environment are not readily available, suggesting it's not widely used in everyday circumstances.

InChI:InChI=1/C7H13NO/c1-2-4-7(3-1)8-5-6-9-7/h8H,1-6H2

Upstream product

• 139524-57-5 N-(benzyloxycarbonyl)-7-aza-1,4-dioxospiro<4.4>nonane 
• 14891-11-3 N-ethoxycarbonyl-3-pyrrolidinone ethylene ketal 

Downstream Products

• 23428-82-2 2-(1,4-dioxa-7-aza-spiro[4.4]nonane-7-carbonyl)-benzoic acid methyl ester 
• 41234-71-3 7-(2-formyl-benzoyl)-1,4-dioxa-7-aza-spiro[4.4]nonane 
• 23428-86-6 7-(2-hydroxymethyl-benzoyl)-1,4-dioxa-7-aza-spiro[4.4]nonane 
• 139524-61-1 1-(2,4-Difluoro-phenyl)-7-(1,4-dioxa-7-aza-spiro[4.4]non-7-yl)-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester 
• 139524-59-7 1-(2,4-Difluoro-phenyl)-7-(1,4-dioxa-7-aza-spiro[4.4]non-7-yl)-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 

Relevant articles and documents

HETEROCYCLIC COMPOUND

Provided is a compound useful for the prophylaxis or treatment of cancer. The present invention relates to a compound represented by formula (I): wherein each symbol in the formula is as defined in the specification, or a salt thereof or a prodrug thereof, which is useful for the prophylaxis or treatment of cancer.

Design, synthesis, and biological evaluation of 14-substituted aromathecins as topoisomerase I inhibitors

The aromathecin or "rosettacin" class of topoisomerase I (top1) inhibitors is effectively a "composite" of the natural products camptothecin and luotonin A and the synthetic indenoisoquinolines. The aromathecins have aroused considerable interest following the isolation and total synthesis of 22-hydroxyacuminatine, a rare cytotoxic natural product containing the 12H-5,11a-diazadibenzo[b,h]fluoren-11-one system. We have developed two novel syntheses of this system and prepared a series of 14-substituted aromathecins as novel antiproliferative topoisomerase I poisons. These inhibitors are proposed to act via an intercalation and "poisoning" mechanism identical to camptothecin and the indenoisoquinolines. Many of these compounds possess greater antiproliferative activity and anti-top 1 activity than the parent unsubstituted compound (rosettacin) and previously synthesized aromathecins, as well as greater top1 inhibitory activity than 22-hydroxyacuminatine. In addition to potentially aiding solubility and localization to the DNA-enzyme complex, nitrogenous substituents located at the 14-position of the aromathecin system have been proposed to project into the major groove of the top1-DNA complex and hydrogen-bond to major-groove amino acids, thereby stabilizing the ternary complex.

AMINOCYCLOHEXYL ETHER COMPOUNDS AND USES THEREOF

Aminocyclohexyl ether compounds of formula (I), or a solvate or pharmaceutically acceptable salt thereof: are disclosed. In said formula, A, X and R, -R5 have the meanings given in the description. The compounds of the present invention may be inco