176-80-7

Usage

Uses

Used in Pharmaceutical Industry:
1-Azaspiro[4.5]decane is used as a building block for the synthesis of various drugs, including antipsychotics and antidepressants, due to its unique spirocyclic structure that facilitates the production of bioactive compounds.
Used in Materials Science:
1-Azaspiro[4.5]decane is used as a component in liquid crystals for its potential to contribute to the development of advanced materials with specific properties.
1-Azaspiro[4.5]decane is also used as a ligand in metal complex catalysts, where it can enhance the efficiency and selectivity of various chemical reactions.
Used in Organic Chemistry:
1-Azaspiro[4.5]decane is used as a chiral auxiliary in asymmetric synthesis, which is crucial for the production of enantiomerically pure compounds, often required in pharmaceuticals and agrochemicals for their biological activity and selectivity.

InChI:InChI=1/C9H17N/c1-2-5-9(6-3-1)7-4-8-10-9/h10H,1-8H2

Upstream product

• 5498-74-8 2-oxo-1-azaspiro<4.5>decane 
• 71648-41-4 1-(2-methoxycarbonylethyl)-1-nitrocyclohexane 
• 108-91-8 cyclohexylamine 
• 155137-20-5 3-(1-Amino-cyclohexyl)-propionic acid ethyl ester 
• 5498-73-7 3-(1-nitro-cyclohexyl)-propionic acid ethyl ester 
• 1122-60-7 1-nitrocyclohexane 
• 6972-66-3 3-(1-nitro-cyclohexyl)-propionitrile 
• 71-36-3 butan-1-ol 

Downstream Products

• 5768-95-6 10-[2-(1-aza-spiro[4.5]dec-1-yl)-ethyl]-10H-phenothiazine 
• 119250-31-6 cyclopent-2-enyl-phenyl-acetic acid-[2-(1-aza-spiro[4.5]dec-1-yl)-ethyl ester] 

Relevant academic research and scientific papers

Straightforward and effective synthesis of γ-aminobutyric acid transporter subtype 2-selective acyl-substituted azaspiro[4.5]decanes

Supply of major metabolites such as γ-aminobutyric acid (GABA), β-alanine and taurine is an essential instrument that shapes signalling, proper cell functioning and survival in the brain and peripheral organs. This background motivates the synthesis of no

Synthesis and evaluation of (piperidinomethylene)bis(phosphonic acid) derivatives as anti-osteoporosis agents

Some (piperidinomethylene)bis(phosphonic acid) derivatives were prepared and their activity to inhibit a rise in serum calcium induced by parathyroid hormone in thyroparathyroidectomised rats was evaluated. Several (4- alkylidene-, 4,4-dialkyl-, or 4-alkyl-4- halopiperidinomethylene)bis(phosphonic acid) derivatives showed considerable inhibitory activity. But compounds having aromatic and polar substituents such as azido, hydroxy, amino and amido on the piperidine ring were generally inactive. In this study, two 4-alkylidene compounds (8a and 8b) and a 4,4- cyclic dialkyl compound (61) showed potent activity when administered either intravenously or perorally.

SYNTHESIS AND REACTIONS OF 1-AZASPIROCYCLES: 1-AZASPIRODECANE AND 1-AZASPIRONONANE RING SYSTEMS.

Nitrocyclohexane reacted with methyl acrylate in the presence of Triton-B to yield nitro-ester (4) which cyclised to spirolactam (5) on treatment with zinc in ethanolic hydrochloric acid.Lactam (5) was reduced to pyrrolidine (7) by lithium aluminium hydri