5498-73-7

Upstream product

• 140-88-5 ethyl acrylate 
• 1122-60-7 1-nitrocyclohexane 
• 552-89-6 2-nitro-benzaldehyde 

Downstream Products

• 6339-94-2 3-(1-amino-cyclohexyl)-propan-1-ol 
• 76877-76-4 3-(1-nitrocyclohexyl) propionic acid 
• 10094-36-7 ethyl 3-cyclohexylpropanoate 
• 155137-20-5 3-(1-Amino-cyclohexyl)-propionic acid ethyl ester 
• 155137-19-2 4-(1-Amino-cyclohexyl)-butyric acid ethyl ester 
• 100453-64-3 4-(1-nitro-cyclohexyl)-butyric acid ethyl ester 
• 144230-49-9 3-(1-nitro-cyclohexyl)-propionyl chloride 
• 180-73-4 1-axaspiro-[5.5]-undecane 
• 5498-74-8 2-oxo-1-azaspiro<4.5>decane 
• 176-80-7 1-azaspiro[4.5]decane 

Relevant academic research and scientific papers

Intermolecular domino Michael/aldol reactions of α,β-unsaturated esters, aromatic aldehydes, and various nucleophiles promoted with a catalytic amount of a guanidine base in DMSO

In DMSO, a catalytic amount of Barton's base (2-t-butyl-1,1,3,3-tetramethylguanidine, BTMG) effectively catalyzed intermolecular three-component reactions of α,β-unsaturated esters, aldehydes, and carbon-, sulfur-, or nitrogen-pronucleophiles to give three-component addition products with the formation of two new σ-bonds: pronucleophiles and aldehydes reacted with α,β-unsaturated esters at their β-positions and α-positions, respectively. Mechanism studies suggested that these reactions proceeded by the first intermolecular Michael addition of anionic nucleophiles that were formed from pronucleophiles with a catalytic amount of BTMG, followed by intermolecular aldol reactions of transient ester enolates even in the presence of more than stoichiometric amounts of acidic pronucleophiles. High nucleophilicity over Br?nsted basicity of transient enolates in polar solvents was observed for transient ester enolates rather than ketone enolates.

Synthesis and evaluation of (piperidinomethylene)bis(phosphonic acid) derivatives as anti-osteoporosis agents

Some (piperidinomethylene)bis(phosphonic acid) derivatives were prepared and their activity to inhibit a rise in serum calcium induced by parathyroid hormone in thyroparathyroidectomised rats was evaluated. Several (4- alkylidene-, 4,4-dialkyl-, or 4-alkyl-4- halopiperidinomethylene)bis(phosphonic acid) derivatives showed considerable inhibitory activity. But compounds having aromatic and polar substituents such as azido, hydroxy, amino and amido on the piperidine ring were generally inactive. In this study, two 4-alkylidene compounds (8a and 8b) and a 4,4- cyclic dialkyl compound (61) showed potent activity when administered either intravenously or perorally.

New Synthetic Methods. Conjugate Addition of Alkyl Groups to Electron Deficient Olefins with Nitroalkanes as Alkyl Anion Equivalents

The sequence of the Michael addition of nitroalkanes and denitration from the adduct provides a new and general method for conjugate addition of primary and secondary alkyl groups to electron deficient olefins such as α,β-unsaturated aldehydes, ketones, esters, nitriles, sulfoxides, and sulfones.

Producing substituted 2-cyclopentenones

A process is provided for producing substituted 2-cyclopentenones represented by the general formula: STR1 where R1, R2, R3, R4, and R5 are hydrogen or lower aliphatic hydrocarbyl groups. The process comprises treating a nitroalkane with a substituted acrylic acid ester in the presence of a base, followed by saponification, to yield a substituted 4-nitropentanoic acid which acid is then treated with strong acid under dehydrative conditions to yield the subject 2-cyclopentenone.