176022-28-9Relevant academic research and scientific papers
Highly antimalaria-active artemisinin derivatives: Biological activity does not correlate with chemical reactivity
Haynes, Richard K.,Ho, Wing-Yan,Chan, Ho-Wai,Fugmann, Burkhard,Stetter, Joerg,Croft, Simon L.,Vivas, Livia,Peters, Wallace,Robinson, Brian L.
, p. 1381 - 1385 (2007/10/03)
New leads for antimalarial drugs? 10-Alkylaminoartemisinin derivatives like that shown display in vivo antimalarial activities greater than those of the parent artemisinin. Previous conclusions regarding the chemical basis for the antimalarial activity of these compounds must be reconsidered.
Structure-activity relationships of the antimalarial agent artemisinin. 3. Total synthesis of (+)-13-carbaartemisinin and related tetra- and tricyclic structures
Avery, Mitchell A.,Fan, Pingchen,Karle, Jean M.,Bonk, Jason D.,Miller, Robert,Goins, D. Keith
, p. 1885 - 1897 (2007/10/03)
Provided by total synthesis, endoperoxides 18, 20, and 22 underwent intramolecular oxymercuration-demercuration leading respectively to formation of an isomeric tetracycle, (1aS,3S, 5aS,6R,8aS,9R,125)-10-deoxo-13- carbaartemisinin (19), (+)-10-deoxo-13-ca
