176038-84-9Relevant articles and documents
Prop-2-ynyloxybenzyloxy substituted phthalocyanine-based polymeric nanoparticles: synthesis, photophysical properties and in?vitro PDT efficacy
Xiao, Shuanghuang,Chen, Xiuqin,Ye, Qiuhao,Chen, Kuizhi,Xiao, Wenling,Guan, Xinqiao,Huang, Bingcheng,Liu, Guowei,Wei, Hui,Peng, Yiru
, p. 1232 - 1244 (2020)
Two prop-2-ynyloxybenzyloxy axially/peripherally substituted zinc/silicon phthalocyanines (YSiPc and YZnPc) were synthesized. They were encapsulated into an amphiphilic block copolymeric micelle polyethylene glycol monomethyl ether-polycaprolactone (MPEG5000–PCL2000) to form polymeric nanoparticles YSiPc@MPEG5000–PCL2000 and YZnPc@MPEG5000–PCL2000. The photophysical and photochemical properties of these polymeric nanoparticles were studied by UV/Vis and fluorescence spectroscopy. The cellular uptake and reactive oxygen species (ROS) production abilities of two polymeric nanoparticles in MCF-7 breast cancer cells were evaluated by confocal laser scanning imaging. YSiPc@MPEG5000–PCL2000 exhibited a higher cellular uptake, higher ROS generation ability as well as higher photodynamic efficacy against MCF-7 cells. YSiPc@MPEG5000–PCL2000 is a promising photosensitizer for photodynamic therapy.
Sequence Control of Macromers via Iterative Sequential and Exponential Growth
Amir, Faheem,Jia, Zhongfan,Monteiro, Michael J.
, p. 16600 - 16603 (2016)
A general strategy through the use of direct azidation of alcohols allowed the sequence control of macromers via both the iterative sequential growth and iterative exponential growth methods. The chemistry was highly efficient in building polymers from a
Clicked (AB)2C-type miktoarm terpolymers: Synthesis, thermal and self-assembly properties, and preparation of nanoporous materials
Song, Jie,Lee, Eunji,Cho, Byoung-Ki
, p. 446 - 456 (2013)
A well-defined (PEO-PS)2-PLA miktoarm terpolymer (1) was synthesized by stepwise click reactions of individually prepared poly(ethylene oxide) (PEO), polystyrene (PS, polymerized by atom transfer radical polymerization), and polylactide (PLA, p
An expeditious click approach towards the synthesis of galactose coated novel glyco-dendrimers and dentromers utilizing a double stage convergent method
Agrahari, Anand K.,Mukherjee, Rishav,Singh., Anoop S.,Tiwari, Vinod K.
, p. 31553 - 31562 (2020/09/21)
The primary motive behind this article is to bring to the forefront a unique kind of dendrimer which has remained a dark horse since its discovery, namely dentromer. We herein report the synthesis of glycodendrimers and glycodentromers crowned with galactose units by harnessing an expeditious synthesis of dendrimer core 18 and dentromer core 19, divergently with branching directionality (1 → 2) and (1 → 3), respectively. A competent, double stage convergent synthetic path was chosen to facilitate ease of refining and spectroscopic elucidations. By exploiting a Cu(i)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction strategy, we successfully developed a new series of galactosylated dendrimers 20, 21, 22, and 24 containing 6, 12, 18, and 18 peripheral galactose units, respectively. We are first to report the practical synthesis of 9-peripheral galactose coated glycodentromer 23 (0th generation) and 27-peripheral galactose coated glycodentromer 25 (1st generation). These synthesized scaffolds were characterized by spectral studies such as 1H, 13C NMR, FT-IR, MALDI-TOF MS, HRMS and SEC analysis. Additionally, gel permeation chromatography depicted the regular progression in size from 6 to 27-peripheral galactose coated glycodendrimers along with glycodentromers, with their high monodispersity. Also, the glyco-dendrimers and dentromers synthesized from two different hypercore units i.e. dendrimers core (18) and dentromer core (19), have been supported by their UV-visible absorbance and emission spectroscopy. This journal is
Supramolecular redox-responsive substrate carrier activity of a ferrocenyl Janus device
Mu, Shengdong,Ling, Qiangjun,Liu, Xiong,Ruiz, Jaime,Astruc, Didier,Gu, Haibin
, p. 31 - 41 (2019/01/24)
Supramolecular Janus compounds have recently attracted increasing attention owing to their dynamic reversible properties, distinct topological structures, and remarkable physicochemical characteristics, e.g., amphiphilicity, heterofunctionality, and high-
Self-assembly of tetraphenylethylene-based dendron into blue fluorescent nanoparticles with aggregation induced enhanced emission §
Krishnan, Nithiyanandan,Ameena, M A Hanna,Atchimnaidu, Siriki,Perumal, Devanathan,Golla, Murali,Krishna, Jithu,Varghese, Reji
, (2018/10/02)
Abstract: Luminescent organic nanoassemblies have received great attention in recent years due to their potential applications in material science and bioimaging. Since most of the fluorophores undergo aggregation-caused quenching in the solid state, thei
Enhanced electro-optic activity of two novel bichromophores which are synthesized by Cu(I) catalyzed click-reaction
He, Yanling,Chen, Lu,Liu, Fenggang,Zhang, Hua,Huo, Fuyang,Chen, Zhuo,Liu, Jialei,Zhen, Zhen,Liu, Xinhou,Bo, Shuhui
, p. 756 - 763 (2017/01/17)
Two novel bichromophores YL1 and YL2 based on traditional aniline chromophore YL were synthesized by Cu(I) catalyzed click-reaction and systematically investigated in this paper. The UV–Vis, electrochemical property, thermal stability and EO activity of t
Direct Enzymatic Branch-End Extension of Glycocluster-Presented Glycans: An Effective Strategy for Programming Glycan Bioactivity
Bayón, Carlos,He, Ning,Deir-Kaspar, Mario,Blasco, Pilar,André, Sabine,Gabius, Hans-Joachim,Rumbero, ángel,Jiménez-Barbero, Jesús,Fessner, Wolf-Dieter,Hernáiz, María J.
, p. 1623 - 1633 (2017/02/10)
The sequence of a glycan and its topology of presentation team up to determine the specificity and selectivity of recognition by saccharide receptors (lectins). Structure–activity analysis would be furthered if the glycan part of a glycocluster could be efficiently elaborated in situ while keeping all other parameters constant. By using a bacterial α2,6-sialyltransferase and a small library of bi- to tetravalent glycoclusters, we illustrate the complete conversion of scaffold-presented lactoside units into two different sialylated ligands based on N-acetyl/glycolyl-neuraminic acid incorporation. We assess the ensuing effect on their bioactivity for a plant toxin, and present an analysis of the noncovalent substrate binding contacts that the added sialic acid moiety makes to the lectin. Enzymatic diversification of a scaffold-presented glycan can thus be brought to completion in situ, offering a versatile perspective for rational glycocluster engineering.
π-Conjugated polymers with pendant coumarins: Design, synthesis, characterization, and interactions with carbon nanotubes
Imit, Mokhtar,Imin, Patigul,Adronov, Alex
, p. 759 - 768 (2016/10/12)
A series of new fluorene-based π-conjugated polymers having coumarin derivatives as part of dendritic side chains were designed and prepared using the Suzuki-Miyaura cross-coupling reaction. A new coumarin derivative bearing a heptyl side chain for solubility was utilized to ensure solubility of the final polymers. It was found that fluorescence resonance energy transfer (FRET) from the coumrains to the polyfluorene backbone was efficient, especially for the polymers decorated with lower-generation dendrons. Each of the polymers was found to interact strongly with the surface of single-walled carbon nanotubes (SWNTs) in THF, and their ability to selectively disperse specific SWNT chiralities was investigated. Photoluminescence studies revealed that the strong polymer emission is efficiently quenched in the corresponding supramolecular complexes with SWNTs. This high quenching efficiency indicates that the coumarin-polymer FRET system can be supramolecularly bound to the surface of (SWNTs to produce an energy transfer system in which the energy absorbed by the donor coumarin chromophores is channeled to the SWNTs.
Synthesis and characterization of novel dendritic compounds bearing a porphyrin core and cholic acid units using "click chemistry"
Aguilar-Ortíz, Edgar,Lévaray, Nicolas,Vonlanthen, Mireille,Morales-Espinoza, Eric G.,Rojas-Aguirre, Yareli,Zhu, Xiao Xia,Rivera, Ernesto
, p. 110 - 120 (2016/05/19)
Four novel dendritic molecules bearing a porphyrin core and peripheral cholic acid units (TPPh(Zn) Tetra-CA, TPPh(2H) Tetra-CA, TPPh(Zn) Octa-CA and TPPh(2H) Octa-CA) have been synthesized by the "click chemistry" approach, using azide-alkyne couplings. These compounds are fully characterized by 1H and 13C NMR spectroscopy and MALDI-TOF. The optical properties of the dendronized porphyrins are studied by absorption and fluorescence spectroscopy in different solvents, in order to study the amphiphilic properties of the cholic acid units in combination with the optical response of the porphyrin unit. After complexation with Zn, the metallated porphyrins (TPPh(Zn) tetra-CA and TPPh(Zn) octa-CA) tend to form J-aggregates in solvents of different polarity, whereas the free base porphyrins TPPh(2H) tetra-CA and TPPh(2H) octa-CA behaved differently. The aggregation phenomenon has been investigated by varying the polarity of the environment, temperature and metallation.
